Issue 3, 2019

Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation

Abstract

Platelet separation is a crucial step for both blood donation and treatment of essential thrombocytosis. Here we present an acoustofluidic device that is capable of performing high-throughput, biocompatible platelet separation using sound waves. The device is entirely made of plastic material, which renders the device disposable and more suitable for clinical use. We used this device to process undiluted human whole blood, and we demonstrate a sample throughput of 20 mL min−1, a platelet recovery rate of 87.3%, and a red/white blood cell removal rate of 88.9%. We preserved better platelet function and integrity for isolated platelets than those which are isolated using established methods. Our device features advantages such as rapid fabrication, high throughput, and biocompatibility, so it is a promising alternative to existing platelet separation approaches.

Graphical abstract: Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation

Supplementary files

Article information

Article type
Paper
Submitted
24 maj 2018
Accepted
19 dec 2018
First published
11 jan 2019

Lab Chip, 2019,19, 394-402

Author version available

Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation

Y. Gu, C. Chen, Z. Wang, P. Huang, H. Fu, L. Wang, M. Wu, Y. Chen, T. Gao, J. Gong, J. Kwun, G. M. Arepally and T. J. Huang, Lab Chip, 2019, 19, 394 DOI: 10.1039/C8LC00527C

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