Issue 1, 2019

Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

Abstract

A novel one-pot epoxide hydrolase/alcohol dehydrogenase/transaminase cascade process for the asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols is reported. The product (S)-β-amino alcohols were obtained in 97–99% ee and 79–99% conversion from readily available racemic epoxides.

Graphical abstract: Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

Supplementary files

Article information

Article type
Communication
Submitted
21 nov 2018
Accepted
04 dec 2018
First published
04 dec 2018

Catal. Sci. Technol., 2019,9, 70-74

Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

J. Zhang, X. Yang, Q. Jia, J. Zhao, L. Gao, W. Gao, H. Chang, W. Wei and J. Xu, Catal. Sci. Technol., 2019, 9, 70 DOI: 10.1039/C8CY02377H

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