Issue 25, 2018

Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines

Abstract

Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell, but are often oxidized in order to modify their surface chemistry for targeting to specific cellular compartments. Here, we assessed the biological impact of this purification process, considering cellular proliferation, uptake, and oxidative stress for graphitic and oxidized nanodiamond surfaces. We show for the first time that oxidized nanodiamonds possess improved biocompatibility compared to graphitic nanodiamonds in breast cancer cell lines, with graphitic nanodiamonds inducing higher levels of oxidative stress despite lower uptake.

Graphical abstract: Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines

Supplementary files

Article information

Article type
Paper
Submitted
15 mar 2018
Accepted
18 maj 2018
First published
19 jun 2018
This article is Open Access
Creative Commons BY license

Nanoscale, 2018,10, 12169-12179

Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines

B. Woodhams, L. Ansel-Bollepalli, J. Surmacki, H. Knowles, L. Maggini, M. de Volder, M. Atatüre and S. Bohndiek, Nanoscale, 2018, 10, 12169 DOI: 10.1039/C8NR02177E

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