Issue 117, 2015

A novel heterobimetallic Ru(ii)–Gd(iii) complex-based magnetoluminescent agent for MR and luminescence imaging

Abstract

A novel heterobimetallic ruthenium(II)–gadolinium(III) complex, Ru–Gd, comprising a luminescent Ru(II) complex, [Ru(bpy)2(phen)]2+ (bpy: 2,2′-bipyridine; phen: 1,10-phenanthroline), and a Gd(III) complex, DOTA–Gd3+ (DOTA: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), has been designed and synthesized as a magnetoluminescent dual-modal imaging agent. The heterobimetallic complex Ru–Gd is water-soluble, biocompatible with low cytotoxicity, strongly luminescent with a long luminescence lifetime and a large Stokes shift, and has comparable longitudinal relaxivity r1 (4.71 mM−1 s−1), which enable the complex to be suitable for luminescence bioimaging and T1-weighted MR imaging. Using Ru–Gd as a contrast agent, the T1-weighted MRI of a Kunming (KM) mouse was successfully carried out. The results demonstrated the availability and validity of our approach for the development of magnetoluminescent dual-modal imaging agents.

Graphical abstract: A novel heterobimetallic Ru(ii)–Gd(iii) complex-based magnetoluminescent agent for MR and luminescence imaging

Supplementary files

Article information

Article type
Paper
Submitted
10 sep 2015
Accepted
02 nov 2015
First published
04 nov 2015

RSC Adv., 2015,5, 96525-96531

A novel heterobimetallic Ru(II)–Gd(III) complex-based magnetoluminescent agent for MR and luminescence imaging

W. Shi, B. Song, M. Tan, Z. Ye and J. Yuan, RSC Adv., 2015, 5, 96525 DOI: 10.1039/C5RA18544K

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