Issue 70, 2024

Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides

Abstract

Oxidation of a thioether linkage in thioether-closed macrocyclic peptides led to collision-induced site-selective linearization of the peptides. This method has allowed for de novo sequencing of thioether macrocyclic peptides. The utility of the sequencing method was demonstrated by identifying the correct peptide sequences from a virtually randomized thioether macrocyclic peptide library.

Graphical abstract: Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides

Supplementary files

Article information

Article type
Communication
Submitted
28 jun 2024
Accepted
02 aug 2024
First published
06 aug 2024

Chem. Commun., 2024,60, 9436-9439

Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides

A. Hayashi, Y. Goto, Y. Saito, H. Suga, J. Morimoto and S. Sando, Chem. Commun., 2024, 60, 9436 DOI: 10.1039/D4CC03179B

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