Issue 15, 2023

Magnetic nanoprobe-enabled lateral flow assays: recent advances

Abstract

In recent years, magnetic nanoparticle sensor technologies have attracted considerable interest in the point-of-care-testing (POCT) field, especially in lateral flow immunoassays (LFIAs). Although the visual signal of magnetic nanoparticles is reduced during an inspection, it can be compensated for by magnetic induction, and detection results can be quantified by magnetic sensors. Sensors that use magnetic nanoparticles (MNPs) as markers can overcome the high background noise of complex samples. In this study, MNP signal detection strategies are described from the perspectives of magnetoresistance, magnetic flux, frequency mixing technology, and magnetic permeability, and the principles and development of each technology are introduced in detail. Typical applications of magnetic nanoparticle sensor technologies are introduced. By describing the advantages and limitations of different sensing strategies, we highlight the development and improvement directions of different sensing strategies. In general, the future development of magnetic nanoparticle sensor technologies will be toward intelligent, convenient, and mobile high-performance detection equipment.

Graphical abstract: Magnetic nanoprobe-enabled lateral flow assays: recent advances

Article information

Article type
Critical Review
Submitted
09 jan 2023
Accepted
13 apr 2023
First published
31 maj 2023

Analyst, 2023,148, 3418-3431

Magnetic nanoprobe-enabled lateral flow assays: recent advances

Y. Zhao, J. Sang, Y. Fu, J. Guo and J. Guo, Analyst, 2023, 148, 3418 DOI: 10.1039/D3AN00044C

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