Issue 81, 2021

Ruthenium(ii)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides

Abstract

A (4+2) annulation under Ru(II)-catalysis is reported using aromatic hydroxamic acid esters as the oxidizing directing group and allylic amides as unactivated olefin coupling partners, delivering a wide variety of aminomethyl isoquinolinones in good to excellent yields. This annulation is distinctive as allylic congeners typically result in allylation and not the annulation. Late-stage derivatization of a bioactive synthetic bile acid has been showcased.

Graphical abstract: Ruthenium(ii)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides

Supplementary files

Article information

Article type
Communication
Submitted
11 aug 2021
Accepted
14 sep 2021
First published
14 sep 2021

Chem. Commun., 2021,57, 10536-10539

Ruthenium(II)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides

C. K. Giri, S. Dana and M. Baidya, Chem. Commun., 2021, 57, 10536 DOI: 10.1039/D1CC04422B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements