Toxicology Research New Talents themed issue
Editor-in-Chief Nigel Gooderham introduces the New Talents themed issue of Toxicology Research.
Contributors to the New Talents issue
Profiles of the authors featured in this Toxicology Research themed issue.
Emerging toxicity models from emerging scientists
Emerging scientists joining the field of Toxicology bring with them novel and exciting approaches and models to assess toxicity.
Autophagy as the effector and player in DNA damage response of cells to genotoxicants
In this review, we provide an overview and discuss the molecular mechanism of DNA damage induced autophagy, and their mutual regulation and its role in cell fate determination in response to genotoxic effects of environmental toxicants.
Beyond a means of exposure: a new view of the mother in toxicology research
Toxicological studies generally view pregnant animals as a conduit through which gestational exposure of offspring to chemicals can be achieved, allowing for the study of developmental toxicity.
Metal toxicity and the p53 protein: an intimate relationship
The relationship between p53, ROS and transition metals.
Silver nanoparticles – wolves in sheep's clothing?
We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.
The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.
Euphorbia tirucalli aqueous extract induces cytotoxicity, genotoxicity and changes in antioxidant gene expression in human leukocytes
The medicinal use of Euphorbia tirucalli has to be made with caution, as our study indicates that the aqueous extract induces genotoxicity and cytotoxicity in human leukocytes
Effects of benzo[a]pyrene on mouse germ cells: heritable DNA mutation, testicular cell hypomethylation and their interaction with nucleotide excision repair
Benzo[a]pyrene induces heritable mutations in male germ cells.
Rescue of cells from apoptosis increases DNA repair in UVB exposed cells: implications for the DNA damage response
Classically, the nucleotide excision repair (NER) of cyclobutane pyrimidine dimers (CPD) is a lengthy process (t1/2 > 48 h).
Paper
Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol
The comprehensive identification and mechanistic analysis of reproductive toxicants constitutes one of the major hurdles in the toxicological assessment of chemicals.
Effect of diselenide administration in thioacetamide-induced acute neurological and hepatic failure in mice
Hepatic encephalopathy is a common complication of severe acute hepatic failure and has been associated with high short-term mortality rates.
Paper
Quantum dot induced cellular perturbations involving varying toxicity pathways
Quantum dots (QD) with varying surface chemistry can have an impact on cellular uptake and a range of indicators for cell perturbation.
In vitro screening of environmental chemicals identifies zearalenone as a novel substrate of the placental BCRP/ABCG2 transporter
The BCRP (ABCG2) transporter is responsible for the efflux of chemicals from the placenta to the maternal circulation.
Eugenia uniflora leaves essential oil induces toxicity in Drosophila melanogaster: involvement of oxidative stress mechanisms
Eugenia uniflora L. (Myrtaceae family), also known as “pitanga”, is a tree species widely used in popular medicine.
Bisphenol-A exposure alters memory consolidation and hippocampal CA1 spine formation through Wnt signaling in vivo and in vitro
Based on Wnt signaling pathway, this study aims to further mechanistically understand memory alteration after BPA exposure.
New approaches to advance the use of genetic toxicology analyses for human health risk assessment
Genetic toxicology testing has a crucial role in the safety assessment of substances of societal value by reducing human exposure to potential somatic and germ cell mutagens.
HBCD and PCBs enhance the cell migration and invasion of HepG2 via the PI3 K/Akt pathway
Exposure to hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) has been proved to result in diversified toxicity, including cancerogenesis.
Uptake of gold nanoparticles in primary human endothelial cells
Single-particle resolution techniques show that endothelial cells internalise 80 nm unmodified gold nanoparticles by endocytosis with subsequent transport to vesicles.
Paper
Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics
This study aims to further mechanistically understand toxic modes of action after chronic arsenic species exposure.
About this collection
This Themed Issue of Toxicology Research showcases the work being conducted by New Talents in toxicology across the globe. It highlights up-and-coming scientists in the early stages of their independent careers, who are internationally recognised for making outstanding contributions to the field.