Themed collection Chemosensors and Molecular Logic
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Recent progress in the development of small-molecule double-locked logic gate fluorescence probes
Recent progress in the development of small-molecule double-locked logic gate fluorescence probes.
Chem. Commun., 2023,59, 11017-11027
https://doi.org/10.1039/D3CC03492E
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Recent applications of organic cages in sensing and separation processes in solution
Cages at work: structural tunability results in tailored properties, which makes these systems suitable for countless applications in sensing and separation processes, both in solution and the solid state.
Chem. Commun., 2023,59, 13668-13678
https://doi.org/10.1039/D3CC04522F
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Lanthanide-based logic: a venture for the future of molecular computing
This review critically examines the use of Ln3+-based molecular logic systems and discusses their potential integration into future molecular photonic-electronic hybrid systems.
Chem. Commun., 2023,59, 7863-7874
https://doi.org/10.1039/D3CC01827J
Excited-state intramolecular proton transfer (ESIPT)-based fluorescent probes for biomarker detection: design, mechanism, and application
Biomarkers are essential in biology, physiology, and pharmacology; thus, their detection is of extensive importance.
Chem. Commun., 2023,59, 2056-2071
https://doi.org/10.1039/D2CC06556H
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Converting pH probes into “turn-on” fluorescent receptors for anions
The feature article outlines the design concept for the construction of “turn-on” fluorescent receptors for anions using fluorescent pH probes. Applications of this concept for the construction of fluorescent receptors for anions are described.
Chem. Commun., 2023,59, 1717-1727
https://doi.org/10.1039/D2CC06194E
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Recent advances in fluorescence chemosensors for ammonia sensing in the solution and vapor phases
In this review article, we have highlighted the recent advancements in the design of fluorescence chemosensors for sensing ammonia both in the solution and vapor phases.
Chem. Commun., 2023,59, 1728-1743
https://doi.org/10.1039/D2CC06529K
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A dual encapsulation strategy to generate anion-responsive luminescent lanthanide hydrogels
We report a new method to generate ion-responsive luminescent hydrogels, involving encapsulation of a luminescent lanthanide probe within crosslinked amphiphilic polymer particles and subsequent entrapment within a hydrogel.
Chem. Commun., 2024,60, 284-287
https://doi.org/10.1039/D3CC04877B
Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6
Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed. We have newly developed a novel NIR mitochondrial probe that exhibits low toxicity.
Chem. Commun., 2023,59, 10109-10112
https://doi.org/10.1039/D3CC03259K
Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine
Hydrogelation of a KLVFF peptide equipped with a C-terminal cysteine residue was realized at a concentration of 0.05 wt% in the presence of Ag+.
Chem. Commun., 2023,59, 9599-9602
https://doi.org/10.1039/D3CC02076B
NMN sensor cocktail: selective sensing of nicotinamide mononucleotide over citric acid
A sensor cocktail, composed of two fluorescent dyes, NBD-B2 and Styryl-51F, selectively senses nicotinamide mononucleotide (NMN) over citric acid through their ratiometric fluorescence changes.
Chem. Commun., 2023,59, 9372-9375
https://doi.org/10.1039/D3CC02501B
Supramolecular self-assembled polymeric nanospheres based on hydrazino naphthalimide functionalised pillar[5]arene for long chain aldehyde detection
A novel fluorescent sensor composed of bis-hydrazino naphthalimide decorated with a pillar[5]arene motif demonstrated highly selective fluorescent sensing of nonanal and octanal via self-assembled supramolecular polymeric nanoparticles.
Chem. Commun., 2023,59, 9207-9210
https://doi.org/10.1039/D3CC02222F
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Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems
Unlabelled bacterial lectin LecA causes enhancement of terbium(III)-centred emission from glycoconjugate, with sensing driven by the lectin's selective carbohydrate-binding.
Chem. Commun., 2023,59, 8384-8387
https://doi.org/10.1039/D3CC02300A
Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT
A simple yet powerful D–A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed.
Chem. Commun., 2023,59, 8127-8130
https://doi.org/10.1039/D3CC02380J
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Spontaneous preparation of a fluorescent ratiometric chemosensor for metal ions using off-the-shelf materials
A self-assembled ratiometric chemosensor, which was prepared by simply mixing an off-the-shelf catechol fluorophore and an off-the-shelf phenylboronic acid derivative, has achieved pattern recognition of metal ions in river water.
Chem. Commun., 2023,59, 7747-7750
https://doi.org/10.1039/D3CC00949A
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Formation of lanthanide luminescent di-metallic helicates in solution using a bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand
Bis-tridentate (1,2,3-triazol-4-yl)picolinamide (tzpa) was used to form Tb(III) double- and triple-stranded di-metallic helicates in solution, where changes in the absorption and the Tb(III) emission were used to monitor the formation of these supramolecular systems.
Chem. Commun., 2023,59, 6044-6047
https://doi.org/10.1039/D3CC01126G
Accurate photoactivation monitoring via the construction of an intramolecular synergistic counteracting mechanism of FRET and IFE
We propose an intramolecular synergistic counteracting strategy of fluorescence resonance energy transfer and the inner filter effect for accurate photoactivation monitoring, to eliminate the influence of the biological microenvironment.
Chem. Commun., 2023,59, 5599-5602
https://doi.org/10.1039/D3CC00951C
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Selective detection of peroxynitrite using an isatin receptor and a naphthalimide fluorophore
A turn-on isatin receptor based naphthalimide fluorescent probe encapsulated in PEG was used to rapidly detect peroxynitrite in cells.
Chem. Commun., 2023,59, 5051-5054
https://doi.org/10.1039/D2CC06425A
Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging
A heavy-atom-free photosensitizer (CI) showed strong singlet oxygen generation, efficient photodynamic therapy and fluorescence bioimaging under two-photon excitation.
Chem. Commun., 2023,59, 4503-4506
https://doi.org/10.1039/D3CC00108C
A white light emitting reconfigurable pyrazoline-naphthalimide logic gate with magnesium, sodium and proton inputs
A 3-pyrazolinyl-naphthalimide is demonstrated as a wavelength-reconfigurable dual-output logic gate that emits orange light on binding Na+ and white light on binding Mg2+.
Chem. Commun., 2023,59, 4459-4462
https://doi.org/10.1039/D2CC06049C
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Transmembrane transport of fluoride studied by time-resolved emission spectroscopy
The encapsulation of a lanthanide-based probe in liposomes allows monitoring of fluoride transmembrane transport using time-resolved emission spectroscopy, which makes it possible study fluorescent transporters.
Chem. Commun., 2023,59, 4185-4188
https://doi.org/10.1039/D3CC00897E
Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+
New Eu(III)-based indicators enable luminescence-based detection of polyphosphate-bound Mg2+ species, a highly dynamic pool of biomolecule-bound magnesium in cells.
Chem. Commun., 2023,59, 3586-3589
https://doi.org/10.1039/D2CC07095B
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Phototransduction in a supramolecular cascade: a mimic for essential features of the vision process
A photoactive supramolecular five-component system mimics essential features of the natural vision process.
Chem. Commun., 2023,59, 3431-3434
https://doi.org/10.1039/D3CC00384A
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SERS microsensors for pH measurements in the lumen and ECM of stem cell derived human airway organoids
SERS microsensors (SERS-MS) are polymer microparticles coated in gold nanoparticles and functionalised with mercaptobenzoic acid. SERS-MS were incorporated into human airway organoids to measured pH optically.
Chem. Commun., 2023,59, 3249-3252
https://doi.org/10.1039/D2CC06582G
Molecularly imprinted and cladded polymers for constructing a portable plasmonic immunoassay for peptides in biofluids
An inexpensive, fast and portable plasmonic immuno-sandwich assay (PISA) based on two molecularly imprinted and cladded polymers (cMIPs) was developed for high-specificity and ultra-sensitive quantitation of C-peptide in urine.
Chem. Commun., 2023,59, 3075-3078
https://doi.org/10.1039/D2CC06550A
γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging
Combining γ-glutamyl transpeptidase and pH dual-responsive sites, an “and” logic gate-based NIR fluorescent probe Si-NH2-Glu was developed for orthotopic breast tumor imaging.
Chem. Commun., 2023,59, 2795-2798
https://doi.org/10.1039/D2CC06568A
Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe
Hydrogen sulfide (H2S) in the endoplasmic reticulum of living systems could be imaged using probe ER-Nap-NBD.
Chem. Commun., 2023,59, 2493-2496
https://doi.org/10.1039/D2CC06645A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme
Here, we describe the design of a molecular probe (NB-ALA) based on the Nile Blue fluorophore, which can detect alanine aminopeptidase enzyme (a kidney damage biomarker) in urine by simple fluorometric measurements.
Chem. Commun., 2023,59, 2481-2484
https://doi.org/10.1039/D2CC05408F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Supramolecular chiral sensing by supramolecular helical polymers
The helicity of the supramolecular porphyrin polymers was determined by the chirality of solvent molecules, which permitted the polymer chains to be used in chiral sensing.
Chem. Commun., 2023,59, 2421-2424
https://doi.org/10.1039/D2CC06502A
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Double click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging
Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin.
Chem. Commun., 2023,59, 1951-1954
https://doi.org/10.1039/D2CC06461H
An entropy-driven DNA nanomachine for microRNA detection using a personal glucose meter
A reliable and portable TDR-PGM nanomachine was facilely constructed for highly sensitive detection of miRNA by integrating the entropy-driven TDR amplifier and the catalytic invertase biocatalyst.
Chem. Commun., 2023,59, 1345-1348
https://doi.org/10.1039/D2CC06479K
Si-rhodamine fluorescent probe for monitoring of hypochlorous acid in the brains of mice afflicted with neuroinflammation
The fluorescent probe SiR-FH realized real-time monitoring of HClO in the brains of mice with LPS-induced neuroinflammation.
Chem. Commun., 2023,59, 1357-1360
https://doi.org/10.1039/D2CC06475H
Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury
An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging.
Chem. Commun., 2023,59, 1145-1148
https://doi.org/10.1039/D2CC04237A
Quinoxaline-fused octaphyrin(2.0.0.0.2.0.0.0). A rudimentary chemosensor
A quinoxaline-fused octaphyrin(2.0.0.0.2.0.0.0) was synthesized by the FeCl3-induced oxidative coupling of an α-free quinoxaline-fused tetrapyrrole.
Chem. Commun., 2023,59, 708-711
https://doi.org/10.1039/D2CC05604F
A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging
A near-infrared fluorescent probe ENBO-ML210 was developed. In vitro and in vivo imaging results showed that it could target and visualize GPX4 in H1299 cells, exhibiting the potential for diagnosis of non-small lung cancer.
Chem. Commun., 2023,59, 294-297
https://doi.org/10.1039/D2CC06161A
A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells
A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells.
Chem. Commun., 2022,58, 13731-13734
https://doi.org/10.1039/D2CC05788C
Three-state fluorescence hydrochromism of a fluorophore–spacer–receptor system with variations in relative humidity
Atmospheric water adsorbed hygroscopically with changes in relative humidity triggers changes in fluorescence emission wavelength for a charged fluorophore leading to three-state fluorescence hydrochromic switching in the solid state.
Chem. Commun., 2022,58, 13463-13466
https://doi.org/10.1039/D2CC05878B
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TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress
We report on a superoxide anion (O2˙−) responsive fluorescent probe called TCF-OTf.
Chem. Commun., 2022,58, 13103-13106
https://doi.org/10.1039/D2CC04662H
An NO-responsive probe for detecting acute inflammation using NIR-II fluorescence/optoacoustic imaging
An activatable probe for detecting acute inflammation has been developed. Nitrosation turns electron-donating methylamine into electron-withdrawing methyl-N-nitroso with turn-on NIR-II fluorescence and optoacoustic signals for imaging.
Chem. Commun., 2022,58, 13123-13126
https://doi.org/10.1039/D2CC05386A
New cell-membrane-anchored near-infrared fluorescent probes for viscosity monitoring
We developed new cell-membrane-anchored fluorescent probes for viscosity detection. Probe MYN-BS has been successfully applied in the monitoring of cell membrane viscosity during temperature change and cell foaming.
Chem. Commun., 2022,58, 12815-12818
https://doi.org/10.1039/D2CC05362D
SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy
A new bioconjugate based on glioblastoma multiforme (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is disclosed.
Chem. Commun., 2022,58, 10941-10944
https://doi.org/10.1039/D2CC03777G
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A fluorescent probe strategy for the detection and discrimination of hydrogen peroxide and peroxynitrite in cells
We report a fluorescent probe strategy that provides the potential to detect and discriminate hydrogen peroxide and peroxynitrite in cells.
Chem. Commun., 2022,58, 10699-10702
https://doi.org/10.1039/D2CC03406A
A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging
A pyridone-based hydrazone probe Sth-NH is established for monitoring the lower lysosomal pH of cancer cells via a turn-on fluorescence mode.
Chem. Commun., 2022,58, 10635-10638
https://doi.org/10.1039/D2CC03999K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
An endoplasmic reticulum targeting green fluorescent protein chromophore-based probe for the detection of viscosity
The occurrence of endoplasmic reticulum (ER) stress is the main cause of a variety of biological processes that are closely related to numerous diseases.
Chem. Commun., 2022,58, 10727-10730
https://doi.org/10.1039/D2CC00118G
Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage
NAN0-N3 and NAN6-N3 could monitor DNA damage induced by the overexpression of H2S.
Chem. Commun., 2022,58, 10500-10503
https://doi.org/10.1039/D2CC04247A
A red-NIR fluorescent probe for rapid and visual detection of acrolein
A red-NIR turn-on fluorescent probe has been developed for rapid, sensitive and colorimetric detection of toxic acrolein.
Chem. Commun., 2022,58, 10080-10083
https://doi.org/10.1039/D2CC03480H
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Two boron atoms versus one: high-performance deep-blue multi-resonance thermally activated delayed fluorescence emitters
Two new deep-blue narrowband multi-resonant emitters, 1B-DTACrs and 2B-DTACrs, one of which shows TADF, based on boron, nitrogen, and oxygen doped nanographenes are reported.
Chem. Commun., 2022,58, 9377-9380
https://doi.org/10.1039/D2CC03347J
About this collection
This themed collection, guest edited by Tony James (University of Bath), Juyoung Yoon (Ewha Womans University), Engin Akkaya (Dalian University of Technology) and Thorfinnur Gunnlaugsson (Trinity College Dublin), on “Chemosensors and Molecular Logic” aims to highlight the current state of the art and future directions of these two interlinked areas. These areas of research were pioneered by Anthony W. Czarnik (21-11-1957) a founding light for “chemosensors” which are compounds of abiotic origin that complex to an analyte reversibly to generate a fluorescence signal and AP DeSilva (29-4-1952) who serendipitously (under a coconut tree) visualized “Molecular Logic” a branch of chemical science that highlights the connection between information technology (engineering and biological) and chemistry.