A facile and efficient strategy for the synthesis of skipped 1,4-dienes from propynolaldehydes and olefins through the Brønsted acid-catalyzed Meyer–Schuster rearrangement/allylic alkenylation is presented.
A new type of nucleophile-intercepted Meyer–Schuster rearrangement mediated by pyridine N-oxide under metal-free conditions using a catalytic amount of acid is disclosed. It enables synthesis of 2-acyl benzofurans and indoles in 56–>99% yields.
A Lewis acid-catalyzed cascade reaction of N-aryl hydroxylamines and propargylic alcohols efficiently synthesizes 2-alkenylanilines and polysubstituted indoles in one pot.
(±)-Stellettin analogs featuring an isoxazoline ring were synthesized. Pharmacological evaluation of the analogs revealed that the α,β-unsaturated ketone structures in stellettins might be important to their cytotoxic activity.
This review explores linear cascade reactions by combining chemo-, photo- and biocatalysts for organic synthesis and strategies to overcome incompatibility issues.