Molecular insights fast-tracked: AI in biosynthetic pathway research

Lijuan Liao, Mengjun Xie, Xiaoshan Zheng, Zhao Zhou, Zixin Deng and Jiangtao Gao

Nat. Prod. Rep., 2025, 42, 911
DOI: 10.1039/D4NP00003J

Machine learning-assisted structure annotation of natural products based on MS and NMR data

Guilin Hu and Minghua Qiu

Nat. Prod. Rep., 2023, 40, 1735
DOI: 10.1039/D3NP00025G

Exploring microbial natural products through NMR-based metabolomics

De-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li and Changsheng Wu

Nat. Prod. Rep., 2025
DOI: 10.1039/D4NP00065J

Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity

Yuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu and Yihua Chen

Nat. Prod. Rep., 2025
DOI: 10.1039/D5NP00008D

Preparation of imidazole-modified paper membrane for selective extraction of gallic acid and its structural and functional analogues from Pomegranate Peel

Xiaoxue Sun, Jingyu Zhang, Xiaohui Han, Shumin Li, Xuerui Zhang and Xiaodong Bi

RSC Adv., 2024, 14, 14202
DOI: 10.1039/D3RA08576G

A deep learning model for type II polyketide natural product prediction without sequence alignment

Jiaquan Huang, Qiandi Gao, Ying Tang, Yaxin Wu, Heqian Zhang and Zhiwei Qin

Digital Discovery, 2023, 2, 1484
DOI: 10.1039/D3DD00107E

Prospecting artificial microbial consortia toward lignin valorization

Jian-Ning Hu, Bo-Chao Gao, Zhi-Hua Liu, Xia Li, Ying-Jin Yuan and Bing-Zhi Li

Chemical Engineering Journal, 2025, 512, 162375
DOI: 10.1016/j.cej.2025.162375

Cyclic dipeptides and the human microbiome: Opportunities and challenges

Charlene Elizabeth Ogilvie and Clarissa Melo Czekster

Bioorganic & Medicinal Chemistry, 2023, 90, 117372
DOI: 10.1016/j.bmc.2023.117372

Artificial intelligence in accelerating vaccine development - current and future perspectives

Rahul Kaushik, Ravi Kant and Myron Christodoulides

Front. Bacteriol., 2023, 2
DOI: 10.3389/fbrio.2023.1258159

Recent advances in genome mining and synthetic biology for discovery and biosynthesis of natural products

Mingpeng Wang, Lei Chen, Zhaojie Zhang and Qinhong Wang

Critical Reviews in Biotechnology, 2025, 45, 236
DOI: 10.1080/07388551.2024.2383754

Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation

Susana P. Gaudêncio, Engin Bayram, Lada Lukić Bilela, Mercedes Cueto, Ana R. Díaz-Marrero, Berat Z. Haznedaroglu, Carlos Jimenez, Manolis Mandalakis, Florbela Pereira, Fernando Reyes and Deniz Tasdemir

Marine Drugs, 2023, 21, 308
DOI: 10.3390/md21050308

Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies

Pritee Chunarkar-Patil, Mohammed Kaleem, Richa Mishra, Subhasree Ray, Aftab Ahmad, Devvret Verma, Sagar Bhayye, Rajni Dubey, Himanshu Singh and Sanjay Kumar

Biomedicines, 2024, 12, 201
DOI: 10.3390/biomedicines12010201

A Survey on Evolutionary Computation-Based Drug Discovery

Qiyuan Yu, Qiuzhen Lin, Junkai Ji, Wei Zhou, Shan He, Zexuan Zhu and Kay Chen Tan

IEEE Trans. Evol. Computat., 2025, 29, 676
DOI: 10.1109/TEVC.2024.3382145

Untargeted Metabolomics and Antibacterial Properties of Streptomyces Species Sourced From Thai Mangrove

Samson Cheruiyot Koech, Atchara Paemanee, Wasu Pathom-aree, Phitchayapak Wintachai, Chonticha Romyasamit, Zdenek Kamenik, Amit Jaisi and Omprakash Sunnapu

Scientifica, 2025, 2025
DOI: 10.1155/sci5/5510017

Secondary metabolites from cyanobacteria: source, chemistry, bioactivities, biosynthesis and total synthesis

Yanchun He, Ying Chen, Huaming Tao, Xuefeng Zhou, Juan Liu, Yonghong Liu and Bin Yang

Phytochem Rev, 2025, 24, 483
DOI: 10.1007/s11101-024-09960-w

The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient

Geoffrey A. Cordell

Nat. Prod. Bioprospect., 2024, 14
DOI: 10.1007/s13659-024-00431-5

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Qichao Hu, Wenwen Zhang, Feng Wei, Meilan Huang, Mengyao Shu, Dan Song, Jianxia Wen, Jundong Wang, Qing Nian, Xiao Ma, Jinhao Zeng and Yanling Zhao

Phytotherapy Research, 2024, 38, 280
DOI: 10.1002/ptr.8043

Hub metabolites at the root–microbiome interface: unlocking plant drought resilience

Hugo A. Pantigoso, Adam Ossowicki, Ioannis A. Stringlis and Víctor J. Carrión

Trends in Plant Science, 2025
DOI: 10.1016/j.tplants.2025.04.007

Synergizing artificial intelligence and probiotics: A comprehensive review of emerging applications in health promotion and industrial innovation

Xin Han, Qingqiu Liu, Yun Li, Meng Zhang, Kaiyang Liu, Lai-Yu Kwok, Heping Zhang and Wenyi Zhang

Trends in Food Science & Technology, 2025, 159, 104938
DOI: 10.1016/j.tifs.2025.104938

Engineering Useful Microbial Species for Pharmaceutical Applications

Amankeldi K. Sadanov, Baiken B. Baimakhanova, Saltanat E. Orasymbet, Irina A. Ratnikova, Zere Z. Turlybaeva, Gul B. Baimakhanova, Aigul A. Amitova, Anel A. Omirbekova, Gulzat S. Aitkaliyeva, Bekzhan D. Kossalbayev and Ayaz M. Belkozhayev

Microorganisms, 2025, 13, 599
DOI: 10.3390/microorganisms13030599

Action of the fungal compound citrinin, a bioherbicide candidate, on photosystem II

Qian Yang, Yanjing Guo, He Wang, Zhi Luo, Ying Chen, Mengyun Jiang, Huan Lu, Bernal E. Valverde, Sheng Qiang, Reto Jörg Strasser and Shiguo Chen

Pest Management Science, 2024, 80, 133
DOI: 10.1002/ps.7513

Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1

Niraj Nag, Tanusree Ray, Rima Tapader, Animesh Gope, Rajdeep Das, Elizabeth Mahapatra, Saibal Saha, Ananda Pal, Parash Prasad and Amit Pal

iScience, 2024, 27, 109828
DOI: 10.1016/j.isci.2024.109828

A Data Deposition Platform for Sharing Nuclear Magnetic Resonance Data

Matthew Pin, Ella F. Poynton, Tamara Jordan, Jonghyeok Kim, Benjamin Ledingham, Jeffrey A. van Santen, Vera Yang, Andrew Maras, Pegah Tavangar, Vasuk Gautam, Harrison Peters, Tanvir Sajed, Brian L. Lee, Hailey A. Shreffler, James T. Koller, Zachary M. Tretter, John R. Cort, Lloyd W. Sumner, David S. Wishart and Roger G. Linington

J. Nat. Prod., 2023, 86, 2554
DOI: 10.1021/acs.jnatprod.3c00795

Small molecule inhibitors targeting m6A regulators

Guotai Feng, Yongya Wu, Yuan Hu, Wen Shuai, Xiao Yang, Yong Li, Liang Ouyang and Guan Wang

J Hematol Oncol, 2024, 17
DOI: 10.1186/s13045-024-01546-5

Applications of machine learning in microbial natural product drug discovery

Autumn Arnold, Jeremie Alexander, Gary Liu and Jonathan M. Stokes

Expert Opinion on Drug Discovery, 2023, 18, 1259
DOI: 10.1080/17460441.2023.2251400

Bacteriogenic metallic and semiconducting nano-system as a potential sustainable solution for one health complexities

Vishal Chaudhary, Sonu Sonu, Pankaj Raizada and Ajeet Kaushik

Advances in Colloid and Interface Science, 2025, 103648
DOI: 10.1016/j.cis.2025.103648

Research Approaches for the Discovery of Trypanocidal Molecular Prototypes from Plants

Aboagye Kwarteng Dofuor

Natural Product Communications, 2025, 20
DOI: 10.1177/1934578X251317114

Enhanced metagenomic strategies for elucidating the complexities of gut microbiota: a review

Xinru Li and Haiyan Lu

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1626002

Progressing microbial genomics: Artificial intelligence and deep learning driven advances in genome analysis and therapeutics

R. Dhaarani and M. Kiranmai Reddy

Intelligence-Based Medicine, 2025, 11, 100251
DOI: 10.1016/j.ibmed.2025.100251

A Comprehensive Overview of Postbiotics with a Special Focus on Discovery Techniques and Clinical Applications

Anand Kumar, Katelyn M. Green and Manmeet Rawat

Foods, 2024, 13, 2937
DOI: 10.3390/foods13182937

Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis

Kuanhui Gao, Longlong Lv, Zhichao Li, Chenmoji Wang, Jiahao Zhang, Daodi Qiu, Haipeng Xue, Zhanwang Xu and Guoqing Tan

Phytotherapy Research, 2025, 39, 162
DOI: 10.1002/ptr.8366

The role of Artificial Intelligence in drug discovery

Samiksha B. Rotake, Pooja R. Hatwar, Ravindra L. Bakal and Shruti I. Meshram

J. Drug Delivery Ther., 2025, 15, 102
DOI: 10.22270/jddt.v15i7.7251

Sensing of Antibiotic–Bacteria Interactions

Anna A. Baranova, Anton P. Tyurin, Vladimir A. Korshun and Vera A. Alferova

Antibiotics, 2023, 12, 1340
DOI: 10.3390/antibiotics12081340

Machine Learning-Driven Discovery and Database of Cyanobacteria Bioactive Compounds: A Resource for Therapeutics and Bioremediation

Renato Soares, Luísa Azevedo, Vitor Vasconcelos, Diogo Pratas, Sérgio F. Sousa and João Carneiro

J. Chem. Inf. Model., 2024, 64, 9576
DOI: 10.1021/acs.jcim.4c00995

Cell membrane bionic magnetic fluorescence nanoplatform combined with ligand fishing technology for natural product active compounds screening

Runuo Wang, Yi Qin, Heng Ye, Hezheng Bai and Longshan Zhao

Microchemical Journal, 2025, 215, 114230
DOI: 10.1016/j.microc.2025.114230

Machine learning-assisted affinity ultrafiltration for bioactive natural products discovery:Application to screening of neuraminidase inhibitors from medicinal herbs

Menghan Chen, Shengyong Ding, Liqing Wang, Tongtong Jian, Yong Yang and Rong Rong

Analytica Chimica Acta, 2025, 1374, 344522
DOI: 10.1016/j.aca.2025.344522