Lipophilic glucose monoesters and glycosides are potent human Mincle agonists

Chriselle D. Braganza, Kristel Kodar, Thomas Teunissen, Sarah K. Andreassend, Ayesha Khan, Mattie S. M. Timmer and Bridget L. Stocker

Org. Biomol. Chem., 2022, 20, 3096
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From the banal to the bizarre: unravelling immune recognition and response to microbial lipids

Laura Burchill and Spencer J. Williams

Chem. Commun., 2022, 58, 925
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Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN

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Chem. Sci., 2024, 15, 15352
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Aryl fucosides: synthesis and evaluation of their binding affinity towards the DC-SIGN receptor

Rohit Chavan, Maurice Besch, Jonathan Lefèbre, Christoph Rademacher and Petra Ménová

Org. Biomol. Chem., 2025
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Mannobioside biomimetics that trigger DC-SIGN binding selectivity

Irene Herrera-González, Michel Thépaut, Elena M. Sánchez-Fernández, Antonio di Maio, Corinne Vivès, Javier Rojo, José M. García Fernández, Franck Fieschi, Pedro M. Nieto and Carmen Ortiz Mellet

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Glycomimetics for the inhibition and modulation of lectins

Steffen Leusmann, Petra Ménová, Elena Shanin, Alexander Titz and Christoph Rademacher

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Thermodynamics-Guided Design Reveals a Cooperative Hydrogen Bond in DC-SIGN-targeted Glycomimetics

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Recent Advances in the Development of Mincle-Targeting Vaccine Adjuvants

Anya F. Weth, Emma M. Dangerfield, Mattie S. M. Timmer and Bridget L. Stocker

Vaccines, 2024, 12, 1320
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Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold

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Receptor basis of biological activity of polysaccharides

Evgenii Generalov and Leonid Yakovenko

Biophys Rev, 2023, 15, 1209
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Glycans and Chirality: Stereoselectivity at the Core of DC‐SIGN's Recognition. A Novel View of the Optimum Minimal Ligand Epitope

J. Daniel Martínez, Reyes Núñez‐Franco, Pablo Valverde, Sandra Delgado, Ana Ardá, Jesús Jiménez‐Barbero, Gonzalo Jiménez‐Oses and F. Javier Cañada

Chemistry A European J, 2025, 31
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From structure to function – Ligand recognition by myeloid C-type lectin receptors

Swantje Fischer, Felix Stegmann, Vinayaga Srinivasan Gnanapragassam and Bernd Lepenies

Computational and Structural Biotechnology Journal, 2022, 20, 5790
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High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin

Irene Herrera‐González, Manuel González‐Cuesta, Michel Thépaut, Eugénie Laigre, David Goyard, Javier Rojo, José M. García Fernández, Franck Fieschi, Olivier Renaudet, Pedro M. Nieto and Carmen Ortiz Mellet

Chemistry A European J, 2024, 30
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Synthesis and biological evaluation of trehalose-based Bi-aryl derivatives as C-type lectin ligands

Omer K. Rasheed, Cassandra Buhl, Jay T. Evans, David Holley and Kendal T. Ryter

Tetrahedron, 2023, 132, 133241
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Water-soluble trehalose glycolipids show superior Mincle binding and signaling but impaired phagocytosis and IL-1β production

M. A. Thathsaranie P. Manthrirathna, Emma M. Dangerfield, Shigenari Ishizuka, Aodhamair Woods, Brenda S. Luong, Sho Yamasaki, Mattie S. M. Timmer and Bridget L. Stocker

Front. Mol. Biosci., 2022, 9
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Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting

Felix Stegmann and Bernd Lepenies

Current Opinion in Chemical Biology, 2024, 82, 102521
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Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists

Asia Marie S. Riel, Viktoria Rungelrath, Tamer A. Elwaie, Omer K. Rasheed, Linda Hicks, George Ettenger, Dai-Chi You, Mira Smith, Cassandra Buhl, Walid Abdelwahab, Shannon M. Miller, Alyson J. Smith, David Burkhart, Jay T. Evans and Kendal T. Ryter

IJMS, 2024, 25, 10031
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6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity

M.A. Thathsaranie P. Manthrirathna, Kristel Kodar, Shigenari Ishizuka, Emma M. Dangerfield, Lu Xiuyuan, Sho Yamasaki, Bridget L. Stocker and Mattie S. M. Timmer

Bioorganic Chemistry, 2023, 133, 106345
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A murine model of DC-SIGN humanization exhibits increased susceptibility against SARS-CoV-2

Yeqing Tu, Yitai Fang, Rui Zheng, Dan Lu, Xiaolan Yang, Liangyan Zhang, Deyu Li, Yakun Sun, Wenjing Yu, Deyan Luo and Hui Wang

Microbes and Infection, 2024, 26, 105344
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