Christopher P. Harper, Anna Day, Maya Tsingos, Edward Ding, Elizabeth Zeng, Spencer D. Stumpf, Yunci Qi, Adam Robinson, Jennifer Greif, Joshua A. V. Blodgett and Gemma Reguera

Appl Environ Microbiol, 2024, 90
DOI: 10.1128/aem.00600-24

Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis

Soonkyu Hwang, Namil Lee, Suhyung Cho, Bernhard Palsson and Byung-Kwan Cho

Front. Mol. Biosci., 2020, 7
DOI: 10.3389/fmolb.2020.00087

Characterization and cytotoxicity evaluation of undescribed anthraquinones from rhizospheric Streptomyces sp. YINM00037 associated with Sophora flavescens

Jian-Mei Lu, Ling Ma, Tian-Peng Xie, Yin-Ting Zhang, Rui Duan, Dan-Dan Xia, Hong-Tao Li, Hao Zhou and Min Yin

Fitoterapia, 2026, 188, 106964
DOI: 10.1016/j.fitote.2025.106964

Negative Correlation between Lipid Content and Antibiotic Activity in Streptomyces: General Rule and Exceptions

Michelle David, Clara Lejeune, Sonia Abreu, Annabelle Thibessard, Pierre Leblond, Pierre Chaminade and Marie-Joelle Virolle

Antibiotics, 2020, 9, 280
DOI: 10.3390/antibiotics9060280

Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311

Humberto E. Ortega, Vitor B. Lourenzon, Marc G. Chevrette, Leonardo L.G. Ferreira, René F. Ramos Alvarenga, Weilan G.P. Melo, Tiago Venâncio, Cameron R. Currie, Adriano D. Andricopulo, Tim S. Bugni and Mônica T. Pupo

Bioorganic & Medicinal Chemistry, 2021, 32, 116016
DOI: 10.1016/j.bmc.2021.116016

Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis

Woo Cheol Lee, Sungjae Choi, Ahjin Jang, Jiwon Yeon, Eunha Hwang and Yangmee Kim

Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-95890-y

Comparative Genomic Analysis of Three Paenibacillus polymyxa Strains Isolated from Termitarium and Identification of Novel Biosynthetic Gene Clusters

Boomiga Rathakrishnan, Venkatesan Dhanalakshmi and Jeyaprakash Rajendhran

Curr Microbiol, 2025, 82
DOI: 10.1007/s00284-025-04164-7

Diversity of Polyketide Synthases and Nonribosomal Peptide Synthetases Revealed Through Metagenomic Analysis of a Deep Oligotrophic Cave

Laima Lukoseviciute, Jolanta Lebedeva and Nomeda Kuisiene

Microb Ecol, 2021, 81, 110
DOI: 10.1007/s00248-020-01554-1

Biosynthetic gene clusters from uncultivated soil bacteria of the Atacama Desert

Constanza M. Andreani-Gerard, Verónica Cambiazo, Mauricio González and Sonny T. M. Lee

mSphere, 2024, 9
DOI: 10.1128/msphere.00192-24

Gut microbiomes of cycad-feeding insects tolerant to β-methylamino-L-alanine (BMAA) are rich in siderophore biosynthesis

Karina Gutiérrez-García, Melissa R L Whitaker, Edder D Bustos-Díaz, Shayla Salzman, Hilda E Ramos-Aboites, Zachary L Reitz, Naomi E Pierce, Angélica Cibrián-Jaramillo and Francisco Barona-Gómez

ISME Communications, 2023, 3
DOI: 10.1038/s43705-023-00323-8

Completed Genomic Sequence ofBacillus thuringiensisHER1410 Reveals aCry-Containing Chromosome, Two Megaplasmids, and an Integrative Plasmidial Prophage

Ana Lechuga, Cédric Lood, Margarita Salas, Vera van Noort, Rob Lavigne and Modesto Redrejo-Rodríguez

G3 Genes|Genomes|Genetics, 2020, 10, 2927
DOI: 10.1534/g3.120.401361

A widespread metabolic gene cluster family in metazoans

Natalie E. Grayson, Paul D. Scesa, Malia L. Moore, Jean-Baptiste Ledoux, Jessica Gomez-Garrido, Tyler Alioto, Todd P. Michael, Immo Burkhardt, Eric W. Schmidt and Bradley S. Moore

Nat Chem Biol, 2025, 21, 1509
DOI: 10.1038/s41589-025-01927-y

Production of Epoxyketone Peptide-Based Proteasome Inhibitors by Streptomyces sp. BRA-346: Regulation and Biosynthesis

Bruna Domingues Vieira, Henrique Niero, Rafael de Felício, Luiz Fernando Giolo Alves, Cristina Freitas Bazzano, Renata Sigrist, Luciana Costa Furtado, Gabriela Felix Persinoti, Leticia Veras Costa-Lotufo and Daniela Barretto Barbosa Trivella

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.786008

Artificial intelligence for natural product drug discovery

Michael W. Mullowney, Katherine R. Duncan, Somayah S. Elsayed, Neha Garg, Justin J. J. van der Hooft, Nathaniel I. Martin, David Meijer, Barbara R. Terlouw, Friederike Biermann, Kai Blin, Janani Durairaj, Marina Gorostiola González, Eric J. N. Helfrich, Florian Huber, Stefan Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A. van Santen, Maria Sorokina, Marcy J. Balunas, Mehdi A. Beniddir, Doris A. van Bergeijk, Laura M. Carroll, Chase M. Clark, Djork-Arné Clevert, Chris A. Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, Willem Jespers, Olga V. Kalinina, Satria A. Kautsar, Hyunwoo Kim, Tiago F. Leao, Joleen Masschelein, Evan R. Rees, Raphael Reher, Daniel Reker, Philippe Schwaller, Marwin Segler, Michael A. Skinnider, Allison S. Walker, Egon L. Willighagen, Barbara Zdrazil, Nadine Ziemert, Rebecca J. M. Goss, Pierre Guyomard, Andrea Volkamer, William H. Gerwick, Hyun Uk Kim, Rolf Müller, Gilles P. van Wezel, Gerard J. P. van Westen, Anna K. H. Hirsch, Roger G. Linington, Serina L. Robinson and Marnix H. Medema

Nat Rev Drug Discov, 2023, 22, 895
DOI: 10.1038/s41573-023-00774-7

Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides

Aske Merrild, Tiziana Svenningsen, Marc G. Chevrette and Thomas Tørring

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202425134

Secondary Metabolite Transcriptomic Pipeline (SeMa-Trap), an expression-based exploration tool for increased secondary metabolite production in bacteria

Mehmet Direnç Mungan, Theresa Anisja Harbig, Naybel Hernandez Perez, Simone Edenhart, Evi Stegmann, Kay Nieselt and Nadine Ziemert

Nucleic Acids Research, 2022, 50, W682
DOI: 10.1093/nar/gkac371

Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium

Zong-Jie Wang, Haibo Zhou, Guannan Zhong, Liujie Huo, Ya-Jie Tang, Youming Zhang and Xiaoying Bian

Org. Lett., 2020, 22, 939
DOI: 10.1021/acs.orglett.9b04490

Marine drugs: Biology, pipelines, current and future prospects for production

Nicolas Papon, Brent R. Copp and Vincent Courdavault

Biotechnology Advances, 2022, 54, 107871
DOI: 10.1016/j.biotechadv.2021.107871

Rhodococcus comparative genomics reveals a phylogenomic-dependent non-ribosomal peptide synthetase distribution: insights into biosynthetic gene cluster connection to an orphan metabolite

Agustina Undabarrena, Ricardo Valencia, Andrés Cumsille, Leonardo Zamora-Leiva, Eduardo Castro-Nallar, Francisco Barona-Gomez and Beatriz Cámara

Microbial Genomics, 2021, 7
DOI: 10.1099/mgen.0.000621

A taxonomically representative strain collection to explore xenobiotic and secondary metabolism in bacteria

Evanthia Kontomina, Vasiliki Garefalaki, Konstantina C. Fylaktakidou, Dorothea Evmorfidou, Athina Eleftheraki, Marina Avramidou, Karen Udoh, Maria Panopoulou, Tamás Felföldi, Károly Márialigeti, Giannoulis Fakis, Sotiria Boukouvala and Pankaj Kumar Arora

PLoS ONE, 2022, 17, e0271125
DOI: 10.1371/journal.pone.0271125

Metabolite diversity of Microcystis strains shows tight correspondence to genotype and may contribute to ecotype specificities

Aurore Huré, Maiwenn Le Meur, Charlotte Duval, Jean-Pierre Bouly, Lou Mary, Manon Quiquand, Michella Dawra, Muriel Gugger, Sébastien Halary and Benjamin Marie

Commun Biol, 2026
DOI: 10.1038/s42003-026-09599-7

Directed Evolution of an Adenylation Domain Alters Substrate Specificity and Generates a New Catechol Siderophore in Escherichia coli

Erin Conley, Caryn S. Wadler, Bailey A. Bell, Ivy Lucier, Caroline Haynie, Sophie Eldred, Valerie Nguyen, Tim S. Bugni and Michael G. Thomas

Biochemistry, 2024, 63, 3126
DOI: 10.1021/acs.biochem.4c00499

Phages in vermicomposts enrich functional gene content and facilitate pesticide degradation in soil

Huizhen Chao, Jose Luis Balcazar, Yunling Wu, Anjuan Cai, Mao Ye, Mingming Sun and Feng Hu

Environment International, 2023, 179, 108175
DOI: 10.1016/j.envint.2023.108175

Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica

Sara Cleto, Kristina Haslinger, Kristala L. J. Prather and Timothy K. Lu

BMC Biol, 2021, 19
DOI: 10.1186/s12915-021-00971-z

Characterizing the evolution of defense in a tripartite marine symbiosis using adaptive dynamics

Prerna Singh, Marjolein Bruijning, Gavriela D Carver, Mohamed S Donia and Charlotte Jessica E Metcalf

Evolution Letters, 2025, 9, 105
DOI: 10.1093/evlett/qrae052

Advances in natural product discovery: strategies, technologies, and insights

Buddha Bahadur Basnet, Zhen-Yi Zhou, Rajesh Basnet, Bin Wei and Hong Wang

Nat. Prod. Bioprospect., 2026, 16
DOI: 10.1007/s13659-025-00556-1

Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359

Cornelia Hermes, René Richarz, Daniel A. Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsubasa Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa E. Müller, Evi Kostenis, Gabriele M. König and Max Crüsemann

Nat Commun, 2021, 12
DOI: 10.1038/s41467-020-20418-3

Adventures on the Routes of Protein Evolution—In Memoriam Dan Salah Tawfik (1955–2021)

Colin Jackson, Agnes Toth-Petroczy, Rachel Kolodny, Florian Hollfelder, Monika Fuxreiter, Shina Caroline Lynn Kamerlin and Nobuhiko Tokuriki

Journal of Molecular Biology, 2022, 434, 167462
DOI: 10.1016/j.jmb.2022.167462

Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386

Rebecca E. McHugh, John T. Munnoch, Andrew J. Roe and Paul A. Hoskisson

Access Microbiology, 2022, 4
DOI: 10.1099/acmi.0.000358

zol and fai: large-scale targeted detection and evolutionary investigation of gene clusters

Rauf Salamzade, Patricia Q Tran, Cody Martin, Abigail L Manson, Michael S Gilmore, Ashlee M Earl, Karthik Anantharaman and Lindsay R Kalan

Nucleic Acids Research, 2025, 53
DOI: 10.1093/nar/gkaf045

DP4+-Based Stereochemical Reassignment and Total Synthesis of Polyenic Macrolactam Muanlactam

Oscar Iglesias-Menduiña, Claudio Martínez, Belén Vaz, Susana Alvarez, Rosana Alvarez and Angel R. de Lera

J. Org. Chem., 2025, 90, 2429
DOI: 10.1021/acs.joc.4c02979

Fimsbactin Siderophores From a South African Marine Sponge Symbiont, Marinomonas sp. PE14‐40

Nompumelelo Philile Praiseworth Ikegwuoha, Thea Hanekom, Elzaan Booysen, Corbyn Jason, Shirley Parker‐Nance, Michael T. Davies‐Coleman, Leonardo Joaquim van Zyl and Marla Trindade

Microbial Biotechnology, 2025, 18
DOI: 10.1111/1751-7915.70155

RETRACTED: Set of Cytochrome P450s Cooperatively Catalyzes the Synthesis of a Highly Oxidized and Rearranged Diterpene-Class Sordarinane Architecture

Qibin Chen, Guanyin Yuan, Tao Yuan, Huiting Zeng, Zheng-Rong Zou, Zong-cai Tu, Jie Gao and Yi Zou

J. Am. Chem. Soc., 2022, 144, 3580
DOI: 10.1021/jacs.1c12427

Metabologenomics analysis of Pseudomonas sp. So3.2b, an Antarctic strain with bioactivity against Rhizoctonia solani

Naydja Moralles Maimone, Mario Cezar Pozza Junior, Lucianne Ferreira Paes de Oliveira, Dorian Rojas-Villalta, Simone Possedente de Lira, Leticia Barrientos and Kattia Núñez-Montero

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1187321

Tistrellabactins A and B Are Photoreactive C-Diazeniumdiolate Siderophores from the Marine-Derived Strain Tistrella mobilis KA081020-065

Christina Makris, Jamie K. Leckrone and Alison Butler

J. Nat. Prod., 2023, 86, 1770
DOI: 10.1021/acs.jnatprod.3c00230

Biosynthesis of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis

Rebecca E. McHugh, John T. Munnoch, Robyn E. Braes, Iain J. W. McKean, Josephine Giard, Andrea Taladriz-Sender, Frederik Peschke, Glenn A. Burley, Andrew J. Roe, Paul A. Hoskisson and Arpita Bose

Appl Environ Microbiol, 2022, 88
DOI: 10.1128/aem.00692-22

ActDES – a curated Actinobacterial Database for Evolutionary Studies

Jana K. Schniete, Nelly Selem-Mojica, Anna S. Birke, Pablo Cruz-Morales, Iain S. Hunter, Francisco Barona-Gomez and Paul A. Hoskisson

Microbial Genomics, 2021, 7
DOI: 10.1099/mgen.0.000498

Global analyses of biosynthetic gene clusters in phytobiomes reveal strong phylogenetic conservation of terpenes and aryl polyenes

Arijit Mukherjee, Hitesh Tikariha, Aditya Bandla, Shruti Pavagadhi, Sanjay Swarup and Aurélie Deveau

mSystems, 2023
DOI: 10.1128/msystems.00387-23

Actinomycetota bioprospecting from ore-forming environments

César Aguilar, Amir Alwali, Madeline Mair, Lorena Rodriguez-Orduña, Haydeé Contreras-Peruyero, Ramya Modi, Carson Roberts, Nelly Sélem-Mojica, Cuauhtemoc Licona-Cassani and Elizabeth Ivy Parkinson

Microbial Genomics, 2024, 10
DOI: 10.1099/mgen.0.001253

Ancient Antibiotics, Ancient Resistance

Nicholas Waglechner, Elizabeth J. Culp, Gerard D. Wright and Karen Bush

EcoSal Plus, 2021, 9
DOI: 10.1128/ecosalplus.ESP-0027-2020

Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics

John S Favate, Kyle S Skalenko, Eric Chiles, Xiaoyang Su, Srujana Samhita Yadavalli and Premal Shah

eLife, 2023, 12
DOI: 10.7554/eLife.87039

Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages

Valérie de Crécy-Lagard, Geoffrey Hutinet, José D. D. Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G. Chevrette, R. M. Madhushi N. Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner and Corrella S. Detweiler

Microbiol Mol Biol Rev, 2024, 88
DOI: 10.1128/mmbr.00199-23

Genome mining for drug discovery: progress at the front end

Richard H Baltz

Journal of Industrial Microbiology and Biotechnology, 2021, 48
DOI: 10.1093/jimb/kuab044

A Specialized Dehydrogenase Provides l‐Phenyllactate for FR900359 Biosynthesis

Sophie Klöppel, René Richarz, Daniel A. Wirtz, Natalia Vasenda, Gabriele M. König and Max Crüsemann

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100569

Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome

Barak Dror, Zongqiang Wang, Sean F. Brady, Edouard Jurkevitch, Eddie Cytryn and Marnix Medema

mSystems, 2020, 5
DOI: 10.1128/mSystems.00866-20

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel and Marnix H. Medema

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-21163-x

Type II Polyketide Synthases: A Bioinformatics‐Driven Approach

Shengling Xie and Lihan Zhang

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202200775

Mobilome-mediated transcriptional activation of biosynthetic gene clusters and its impact on strain competitiveness in food fermentation microbiomes

Lei Xu, Jian-Yu Jiao, Chen Ling, Ru-Bing Du, Qun Wu, Yan Xu and Wen-Jun Li

Microbiome, 2025, 13
DOI: 10.1186/s40168-025-02180-0

Out of the Abyss: Genome and Metagenome Mining Reveals Unexpected Environmental Distribution of Abyssomicins

Alba Iglesias, Adriel Latorre-Pérez, James E. M. Stach, Manuel Porcar and Javier Pascual

Front. Microbiol., 2020, 11
DOI: 10.3389/fmicb.2020.00645

Discovery of an Antarctic Ascidian-Associated Uncultivated Verrucomicrobia with Antimelanoma Palmerolide Biosynthetic Potential

Alison E. Murray, Chien-Chi Lo, Hajnalka E. Daligault, Nicole E. Avalon, Robert W. Read, Karen W. Davenport, Mary L. Higham, Yuliya Kunde, Armand E. K. Dichosa, Bill J. Baker, Patrick S. G. Chain and Barbara J. Campbell

mSphere, 2021, 6
DOI: 10.1128/mSphere.00759-21

Microbial communities associated with marine sponges from diverse geographic locations harbor biosynthetic novelty

Vincent V. Nowak, Peng Hou, Jeremy G. Owen and John R. Spear

Appl Environ Microbiol, 2024, 90
DOI: 10.1128/aem.00726-24

Biomimetic engineering of nonribosomal peptide synthesis

Kexin Zhang and Hajo Kries

Biochemical Society Transactions, 2023, 51, 1521
DOI: 10.1042/BST20221264

Phenotypic heterogeneity in Streptomyces colonies

Paul A Hoskisson, Francisco Barona-Gómez and Daniel E Rozen

Current Opinion in Microbiology, 2024, 78, 102448
DOI: 10.1016/j.mib.2024.102448

Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future

Irina Ivshina, Grigory Bazhutin and Elena Tyumina

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.967127

Biosynthesis of Nonribosomal Peptides Chitinimides Reveal a Special Type of Thioesterase Domains

Weijing Niu, Jiaqi Liu, Yuwei Duan, Lin Zhong, Linlin Pang, Guannan Zhong, Youming Zhang and Xiaoying Bian

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402763

Evolution and Ecology of Streptomyces

David M. Norte, Luis Alfredo Avitia-Dominguez and Daniel E. Rozen

Annual Review of Microbiology, 2025, 79, 383
DOI: 10.1146/annurev-micro-051524-032254

Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins

Jaime Felipe Guerrero Garzón, Martin Zehl, Olha Schneider, Inmaculada Tocino Marquez, Christian Rückert-Reed, Jörn Kalinowski and Sergey B. Zotchev

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-17585-y

In-silico and In-vitro screening of phytoconstituents from Cassia absus as potential inhibitors of MraY/MurG - the key bacterial cell wall biosynthesis enzymes

Gurpreet Singh, Prabhjit Kaur, Pratibha Misser, Vaneet Kumar, Satwinderjeet Kaur, Saroj Arora and Rajbir Singh

Food Chemistry Advances, 2025, 7, 100995
DOI: 10.1016/j.focha.2025.100995

Phylogenetic analysis of the salinipostin γ-butyrolactone gene cluster uncovers new potential for bacterial signalling-molecule diversity

Kaitlin E. Creamer, Yuta Kudo, Bradley S. Moore and Paul R. Jensen

Microbial Genomics, 2021, 7
DOI: 10.1099/mgen.0.000568

Development of platforms for functional characterization and production of phenazines using a multi-chassis approach via CRAGE

Jing Ke, Zhiying Zhao, Cameron R. Coates, Michalis Hadjithomas, Andrea Kuftin, Katherine Louie, David Weller, Linda Thomashow, Nigel J. Mouncey, Trent R. Northen and Yasuo Yoshikuni

Metabolic Engineering, 2022, 69, 188
DOI: 10.1016/j.ymben.2021.11.012

Role is in the eye of the beholder—the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae

Nathalie N S E Henriksen, Laura L Lindqvist, Mario Wibowo, Eva C Sonnenschein, Mikkel Bentzon-Tilia and Lone Gram

FEMS Microbiology Reviews, 2022, 46
DOI: 10.1093/femsre/fuac007

Evolution-inspired engineering of anthracycline methyltransferases

Pedro Dinis, Heli Tirkkonen, Benjamin Nji Wandi, Vilja Siitonen, Jarmo Niemi, Thadée Grocholski, Mikko Metsä-Ketelä and Christopher Dupont

PNAS Nexus, 2023, 2
DOI: 10.1093/pnasnexus/pgad009

Exploring the biosynthetic gene clusters in Brevibacterium: a comparative genomic analysis of diversity and distribution

Andrés Cumsille, Néstor Serna-Cardona, Valentina González, Fernanda Claverías, Agustina Undabarrena, Vania Molina, Francisco Salvà-Serra, Edward R.B. Moore and Beatriz Cámara

BMC Genomics, 2023, 24
DOI: 10.1186/s12864-023-09694-7

Evolutionary repurposing of a metabolic thiolase complex enables antibiotic biosynthesis

Ge Liao, Ruolan Sun, Zilin Shen, Zhiteng Luo, Cuiping Pang, Zhuanglin Shen, Anfu Wei, Chengneng Mi, Gengfan Wu, Fengfang Li, Yong-Xin Li, Kin Kuan HOI, Xiaojing Pan and Xiaoyu Tang

Nat Commun, 2026
DOI: 10.1038/s41467-026-68910-6

cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters

Cameron L M Gilchrist, Thomas J Booth, Bram van Wersch, Liana van Grieken, Marnix H Medema, Yit-Heng Chooi and Aida Ouangraoua

Bioinformatics Advances, 2021, 1
DOI: 10.1093/bioadv/vbab016

An Assessment of Chemical Diversity in Microbial Natural Products

Roger G. Linington

ACS Cent. Sci., 2025, 11, 1536
DOI: 10.1021/acscentsci.5c00804

Global Map of Specialized Metabolites Encoded in Prokaryotic Plasmids

Zaki Saati-Santamaría and Olaya Rendueles

Microbiol Spectr, 2023, 11
DOI: 10.1128/spectrum.01523-23

Polymer degrading marine Microbulbifer bacteria: an un(der)utilized source of chemical and biocatalytic novelty

Weimao Zhong and Vinayak Agarwal

Beilstein J. Org. Chem., 2024, 20, 1635
DOI: 10.3762/bjoc.20.146

Nutrient Availability Shifts the Biosynthetic Potential of Soil-Derived Microbial Communities

Marc G. Chevrette, Bradley W. Himes and Camila Carlos-Shanley

Curr Microbiol, 2022, 79
DOI: 10.1007/s00284-021-02746-9

Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics

John S Favate, Kyle S Skalenko, Eric Chiles, Xiaoyang Su, Srujana Samhita Yadavalli and Premal Shah

eLife, 2023, 12
DOI: 10.7554/eLife.87039.3

Identification of SARS-CoV-2 3CLpro inhibitors from marine actinomycetes through integrated phylogeny-based metabolomics with functional screening and bioinformatic analysis

Doralyn S. Dalisay, Jomari C. Mateo, Jade Joshua R. Teodosio, Lucille Marie S. Jusa, Diane Monique S. Baladjay, Leighiara S. de Guzman, Lex Aliko P. Balida and Jamia Azdina Jamal

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-25354-0

The Landscape of Recombination Events That Create Nonribosomal Peptide Diversity

Martin Baunach, Somak Chowdhury, Pierre Stallforth, Elke Dittmann and Miriam Barlow

Molecular Biology and Evolution, 2021, 38, 2116
DOI: 10.1093/molbev/msab015

Chromosomal organization of biosynthetic gene clusters, including those of nine novel species, suggests plasticity of myxobacterial specialized metabolism

Andrew Ahearne, Kayleigh E. Phillips, Thomas Knehans, Miranda Hoing, Scot E. Dowd and David Cole Stevens

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1227206

Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism

Paul A. Hoskisson, Ryan F. Seipke and Gerard D. Wright

mBio, 2020, 11
DOI: 10.1128/mBio.02642-20

Vertical Inheritance Facilitates Interspecies Diversification in Biosynthetic Gene Clusters and Specialized Metabolites

Alexander B. Chase, Douglas Sweeney, Mitchell N. Muskat, Dulce G. Guillén-Matus, Paul R. Jensen and Jacques Ravel

mBio, 2021, 12
DOI: 10.1128/mBio.02700-21

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami and Martin Baunach

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202502461

Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?

Lianet Noda-Garcia and Dan S. Tawfik

Current Opinion in Chemical Biology, 2020, 59, 147
DOI: 10.1016/j.cbpa.2020.05.011

In Quest for Polyenic Macrolactam JBIR‐150 Identity: Stereoselective Synthesis of DP4+‐Based Purported Structure and Biogenetically Inspired Positional Stereoisomers

Oscar Iglesias‐Menduiña, Claudio Martínez, Ariel M. Sarotti, Rosana Alvarez and Angel R. de Lera

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202501861

Conjugation Mediates Large-Scale Chromosomal Transfer in Streptomyces Driving Diversification of Antibiotic Biosynthetic Gene Clusters

Caroline Choufa, Pauline Gascht, Hugo Leblond, Anthony Gauthier, Michiel Vos, Cyril Bontemps, Pierre Leblond and Miriam Barlow

Molecular Biology and Evolution, 2024, 41
DOI: 10.1093/molbev/msae236

Mining genomes to illuminate the specialized chemistry of life

Marnix H. Medema, Tristan de Rond and Bradley S. Moore

Nat Rev Genet, 2021, 22, 553
DOI: 10.1038/s41576-021-00363-7

Recent Advances in the Synthetic Biology of Natural Drugs

Chun-Qiang Li, Hong-Mei Lei, Qian-Yi Hu, Guo-Hong Li and Pei-Ji Zhao

Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.691152

Microbiome composition modulates secondary metabolism in a multispecies bacterial community

Marc G. Chevrette, Chris S. Thomas, Amanda Hurley, Natalia Rosario-Meléndez, Kris Sankaran, Yixing Tu, Austin Hall, Shruthi Magesh and Jo Handelsman

Proc. Natl. Acad. Sci. U.S.A., 2022, 119
DOI: 10.1073/pnas.2212930119

Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides

Aske Merrild, Tiziana Svenningsen, Marc G. Chevrette and Thomas Tørring

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202425134

nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale

Isabel Nuñez Santiago, Nataliia V. Machushynets, Marija Mladic, Doris A. van Bergeijk, Somayah S. Elsayed, Thomas Hankemeier and Gilles P. van Wezel

Commun Chem, 2024, 7
DOI: 10.1038/s42004-024-01153-y

Transporter genes in biosynthetic gene clusters predict metabolite characteristics and siderophore activity

Alexander Crits-Christoph, Nicholas Bhattacharya, Matthew R. Olm, Yun S. Song and Jillian F. Banfield

Genome Res., 2021, 31, 239
DOI: 10.1101/gr.268169.120