Issue 16, 2024

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Abstract

Hydrogen peroxide (H2O2) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy. However, the concentration of intracellular H2O2 limits its application. Some materials could enhance the concentration of intracellular H2O2 to strengthen antitumor therapy. In this review, the recent advances in H2O2-supplying materials in terms of promoting intracellular H2O2 production and exogenous H2O2 supply are summarized. Then the mechanism of H2O2-supplying materials for tumor therapy is discussed from three aspects: reconstruction of the tumor hypoxia microenvironment, enhancement of oxidative stress, and the intrinsic anti-tumor ability of H2O2-supplying materials. In addition, the application of H2O2-supplying materials for tumor therapy is discussed. Finally, the future of H2O2-supplying materials is presented. This review aims to provide a novel idea for the application of H2O2-supplying materials in tumor therapy.

Graphical abstract: Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Article information

Article type
Review Article
Submitted
11 Ube 2024
Accepted
28 Jan 2024
First published
16 Upu 2024

Biomater. Sci., 2024,12, 4083-4102

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

X. Zhang, M. Li, Y. Tang, M. Zheng and X. Liang, Biomater. Sci., 2024, 12, 4083 DOI: 10.1039/D4BM00366G

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