Issue 11, 2024

Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering

Abstract

Repair of bone defects exceeding a critical size has been always a big challenge in clinical practice. Tissue engineering has exhibited great potential to effectively repair the defects with less adverse effect than traditional bone grafts, during which how to induce vascularized bone formation has been recognized as a critical issue. Therefore, recently many studies have been launched to attempt to promote osteogenesis–angiogenesis coupling. This review summarized comprehensively and explored in depth current efforts to ameliorate the coupling of osteogenesis and angiogenesis from four aspects, namely the optimization of scaffold components, modification of scaffold structures, loading strategies for bioactive substances, and employment tricks for appropriate cells. Especially, the advantages and the possible reasons for every strategy, as well as the challenges, were elaborated. Furthermore, some promising research directions were proposed based on an in-depth analysis of the current research. This paper will hopefully spark new ideas and approaches for more efficiently boosting new vascularized bone formations.

Graphical abstract: Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering

Article information

Article type
Review Article
Submitted
12 Tsh 2023
Accepted
15 Mme 2024
First published
16 Mme 2024

Biomater. Sci., 2024,12, 2801-2830

Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering

Z. Xu, B. Wang, R. Huang, M. Guo, D. Han, L. Yin, X. Zhang, Y. Huang and X. Li, Biomater. Sci., 2024, 12, 2801 DOI: 10.1039/D3BM02017G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements