Issue 10, 2024

In situ setup for screening of drug permeation by NMR spectroscopy

Abstract

There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.

Graphical abstract: In situ setup for screening of drug permeation by NMR spectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
11 Pun 2023
Accepted
30 Tsh 2023
First published
08 Phe 2024

Anal. Methods, 2024,16, 1468-1472

In situ setup for screening of drug permeation by NMR spectroscopy

M. Mildner, S. Hanio, S. Endres, L. Scheller, B. Engel, L. Castañar, L. Meinel and A. Pöppler, Anal. Methods, 2024, 16, 1468 DOI: 10.1039/D3AY01995K

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