Issue 48, 2023

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Abstract

Zinc (Zn) is one of the most important trace elements in the human body and plays a key role in various physiological processes, especially in bone metabolism. Zn-containing materials have been reported to enhance bone repair through promoting cell proliferation, osteogenic activity, angiogenesis, and inhibiting osteoclast differentiation. Therefore, Zn-based biomaterials are potential substitutes for traditional bone grafts. In this review, the specific mechanisms of bone formation promotion by Zn-based biomaterials were discussed, and recent developments in their application in bone tissue engineering were summarized. Moreover, the challenges and perspectives of Zn-based biomaterials were concluded, revealing their attractive potential and development directions in the future.

Graphical abstract: Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Article information

Article type
Review Article
Submitted
17 Pha 2023
Accepted
11 Pun 2023
First published
13 Pun 2023

J. Mater. Chem. B, 2023,11, 11405-11425

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

X. Wen, J. Wang, X. Pei and X. Zhang, J. Mater. Chem. B, 2023, 11, 11405 DOI: 10.1039/D3TB01874A

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