Issue 47, 2021

Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout

Abstract

In this paper, we focused on the influence of common serum cations on monosodium urate monohydrate (MSUM) crystal nucleation determined from cumulative probability distributions (CPDs) of solute crystal nucleation events as a function of time. Surprisingly, with an increase in the concentration of additive ions, striking “opposite effects” were observed for cations, enhancing nucleation at first followed by suppressing nucleation at physiological pH and ionic strength. This enhancing nucleation phenomenon cannot be explained based on colloidal theories or simple descriptors, such as ion size, but it is consistent with the cationic efficacy for inducing an increase in the proportion of growth units of MSUM.

Graphical abstract: Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout

Supplementary files

Article information

Article type
Paper
Submitted
01 Leo 2021
Accepted
02 Pun 2021
First published
08 Pun 2021

CrystEngComm, 2021,23, 8411-8417

Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout

A. Da, A. Ren, R. Cheng, X. Zhang, Y. Pan, C. Ou, T. Fu and Y. Liu, CrystEngComm, 2021, 23, 8411 DOI: 10.1039/D1CE01178B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements