Issue 33, 2020

Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

Abstract

Hypochlorite is an important active oxygen species formed in living organisms, and rapid and highly sensitive detection of trace hypochlorite is of great significance for understanding the mechanism of diseases caused by abnormal hypochlorite concentrations at an early stage. Although aggregation-induced emission (AIE) probes are highly important for analyte de-tection in living organisms, there is a lack of AIE probes for hypochlorite detection. In this study, two AIE probes based on benzothiazole derivatives (BTD-1 and BTD-2) were designed and synthesized. Both probes exhibited good AIE charac-teristics and allowed different visual detection for hypochlorite. Additionally, the two probes could be used to detect endogenous hypochlorite in mitochondria and were successfully applied for in vivo hypochlorite imaging in zebrafish.

Graphical abstract: Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

Supplementary files

Article information

Article type
Paper
Submitted
15 Jan 2020
Accepted
06 Upu 2020
First published
06 Upu 2020

J. Mater. Chem. B, 2020,8, 7375-7381

Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

X. Zhong, Q. Yang, Y. Chen, Y. Jiang and Z. Dai, J. Mater. Chem. B, 2020, 8, 7375 DOI: 10.1039/D0TB01496F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements