Issue 8, 2017

An aza-BODIPY photosensitizer for photoacoustic and photothermal imaging guided dual modal cancer phototherapy

Abstract

Developing biocompatible, near infrared absorbing, and multi-functional photosensitizers is crucial for effective cancer phototherapy. In this contribution, a BF2 chelate of [4-iodo-5-(4-bromophenyl)-3-(4-methoxyphenyl)-1H-pyrrol-2-yl][4-iodo-5-(4-bromophenyl)-3-(4-methoxyphenyl)pyrrol-2-ylidene]amine (IABDP) with high singlet oxygen generation efficiency (∼92%) has been designed and synthesized. Soluble and near infrared absorbing nanoparticles (NPs) can be simply obtained from the self-assembly of IABDP molecules, which have a high photothermal conversion efficiency (∼37.9%). Under irradiation of a broadband Xenon lamp, IABBDP NPs are able to serve as common photosensitizers for photothermal imaging (PTI) and photoacoustic imaging (PAI) guided simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT). Compared to the usual combined strategies that require two distinct photosensitizers and two excitation sources, the IABBDP NP based approach is simplified considerably, and hence is more convenient, reliable, and cost effective. Both in vitro and in vivo studies confirm the good biosafety and prominent anti-tumor phototoxicity of IABDP NPs. Finally, we demonstrate that the imaging guided synergistic dual modal phototherapy enabled by IABDP NPs can essentially inhibit tumor growth (87.2% inhibition) in mice without causing considerable side-effects, testifying the great potential of this multi-functional organic photosensitizer for clinical use.

Graphical abstract: An aza-BODIPY photosensitizer for photoacoustic and photothermal imaging guided dual modal cancer phototherapy

Supplementary files

Article information

Article type
Paper
Submitted
16 Pun 2016
Accepted
17 Phe 2017
First published
17 Phe 2017

J. Mater. Chem. B, 2017,5, 1566-1573

An aza-BODIPY photosensitizer for photoacoustic and photothermal imaging guided dual modal cancer phototherapy

Q. Tang, W. Si, C. Huang, K. Ding, W. Huang, P. Chen, Q. Zhang and X. Dong, J. Mater. Chem. B, 2017, 5, 1566 DOI: 10.1039/C6TB02979E

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