Issue 11, 2015

Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles

Abstract

An unprecedented silver-catalyzed 1,3-dipolar cycloaddition reaction of isocyanides with diazo compounds to afford 1,4-disubstituted 1,2,3-triazoles is reported. This reaction exhibits remarkable features, such as high regioselectivity, mild reaction conditions, easily available substrates with simple operation, and good yields with a broad spectrum of substrates. It constitutes an alternative to the well-known CuAAC click reaction.

Graphical abstract: Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles

Supplementary files

Article information

Article type
Research Article
Submitted
09 Upu 2015
Accepted
31 Pha 2015
First published
01 Leo 2015

Org. Chem. Front., 2015,2, 1468-1474

Author version available

Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles

S. Wang, L. Yang, J. Zeng, Y. Zheng and J. Ma, Org. Chem. Front., 2015, 2, 1468 DOI: 10.1039/C5QO00219B

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