Issue 3, 2014

Sterically demanding aryl–alkyl Suzuki–Miyaura coupling

Abstract

Efficient sterically demanding aryl–alkyl Suzuki–Miyaura coupling between di-ortho-substituted aryl halides and secondary alkylboronic acids has been achieved with a Pd-AntPhos catalyst that has shown high reactivity and a broad substrate scope with unprecedented steric hindrance. The methodology has facilitated the synthesis of molecular gears such as by cross-coupling.

Graphical abstract: Sterically demanding aryl–alkyl Suzuki–Miyaura coupling

Supplementary files

Article information

Article type
Research Article
Submitted
22 Phe 2014
Accepted
19 Kol 2014
First published
17 Ube 2014

Org. Chem. Front., 2014,1, 225-229

Author version available

Sterically demanding aryl–alkyl Suzuki–Miyaura coupling

C. Li, G. Xiao, Q. Zhao, H. Liu, T. Wang and W. Tang, Org. Chem. Front., 2014, 1, 225 DOI: 10.1039/C4QO00024B

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