Issue 28, 2025

Organic mechanoluminescent nanoparticles for biomedical applications

Abstract

Mechanoluminescence has emerged as a promising tool for biomedical applications, particularly when paired with ultrasound to enable remote activation. These mechanoluminescent systems have shown potential by offering non-electrical, remote control over biological processes, particularly in fields of neuromodulation and bioimaging. Among these systems, organic mechanoluminescent nanoparticles have garnered attention for their biocompatibility, structural flexibility, light weight properties, and biodegradability, positioning them as ideal candidates for next-generation biomedical devices. This review summarizes recent progress on new designs, discoveries, and mechanisms in the research of organic mechanoluminescent materials, with a focus on their innovative applications in neuromodulation, bioimaging and theranostics; meanwhile also exploring their potential in optophysiology and other biomedical applications. By highlighting the advances of organic mechanoluminescent systems, this review underscores their transformative potential in enabling novel light-mediated bioapplications.

Graphical abstract: Organic mechanoluminescent nanoparticles for biomedical applications

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Article information

Article type
Review Article
Submitted
04 Mme 2025
Accepted
22 Jan 2025
First published
23 Jan 2025
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2025,16, 12702-12717

Organic mechanoluminescent nanoparticles for biomedical applications

C. Gu, X. Liu, B. Song, W. Wang, W. He and H. Wang, Chem. Sci., 2025, 16, 12702 DOI: 10.1039/D5SC02526E

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