Issue 3, 2024

Activatable fluorescent probes for early diagnosis and evaluation of liver injury

Abstract

With the increase in people's living standards, the number of patients suffering from liver injury keeps on increasing. Traditional diagnostic methods can no longer meet the needs of early and accurate diagnosis due to their limitations in application. However, fluorescent probes based on different fluorophores and nanomaterials have been gradually lighting up medical research due to their unique properties, such as high specificity and non-invasiveness. In addition, accurate identification of the different types of liver injury biomarkers can significantly improve the level of early diagnosis. Therefore, this review reviews the fluorescent probes used in the detection of biomarkers of liver injury over recent years and briefly summarizes the corresponding biomarkers of different types of liver injury. Impressively, this review also lists the structures and the response mechanisms of the different probes, and concludes with an outlook, suggesting directions in which improvements can be made. Finally, we hope that this review will contribute to the further development of fluorescent probes for the early diagnosis and assessment of liver injury.

Graphical abstract: Activatable fluorescent probes for early diagnosis and evaluation of liver injury

Article information

Article type
Critical Review
Submitted
24 Leo 2023
Accepted
14 Tsh 2023
First published
15 Tsh 2023

Analyst, 2024,149, 638-664

Activatable fluorescent probes for early diagnosis and evaluation of liver injury

P. Lin, S. Jiang, T. Liu, X. Yuan, K. Luo, C. Xie, X. Zhao and L. Zhou, Analyst, 2024, 149, 638 DOI: 10.1039/D3AN01631E

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