Issue 21, 2022

An automatic whole blood analyzer for renal function analysis with a centrifugal microfluidic device

Abstract

In recent years, chronic kidney disease (CKD) has received widespread attention as one of the fastest growing non-communicable diseases (NCD) worldwide. Here, a clinical biochemical detection system based on a centrifugal microfluidic chip was designed to simplify the rapid detection of renal function indices. A photosensor was used to design an optical signal acquisition structure that can detect products or substrates after enzymatic reactions of uric acid, creatinine, and urea. The weak optical signals collected from this structure were processed using a pre-designed amplifying circuit and a software algorithm to calculate absorbance. The relationship between absorbance and concentration was established according to the Beer–Lambert law. The results indicated good stability and accuracy of the system, which is 21.3 cm × 16.5 cm × 19 cm in size as compared to other detection systems due to the adoption of a centrifugal microfluidic chip. It was portable and easy to operate, in addition to its ability to rapidly detect renal function indices. This system exhibits great potential for the detection of highly integrated point-of-care testing in the future.

Graphical abstract: An automatic whole blood analyzer for renal function analysis with a centrifugal microfluidic device

Article information

Article type
Paper
Submitted
25 Upu 2022
Accepted
20 Leo 2022
First published
27 Leo 2022

Analyst, 2022,147, 4804-4814

An automatic whole blood analyzer for renal function analysis with a centrifugal microfluidic device

C. Wang, Y. Fu, J. Guo and J. Guo, Analyst, 2022, 147, 4804 DOI: 10.1039/D2AN01218A

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