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A facile approach is proposed toward metal-containing single-chain composite nanoparticles by intramolecular crosslinking in concentrated solutions at ambient temperature. Both introducing electrostatic repulsion and crosslinking by coordination with metal ions are fast and performed under mild conditions. The functional nanoparticles are promising as artificial enzymes.

Graphical abstract: Facile intramolecular crosslinking of polymers by metallic coordination in concentrated solutions

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