Issue 22, 2020

Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

Abstract

We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.

Graphical abstract: Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
12 Phe 2020
Accepted
12 Kol 2020
First published
18 Kol 2020

J. Mater. Chem. B, 2020,8, 4841-4845

Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

L. Gao, L. Zhang, X. Zhu, J. Chen, M. Zhao, S. Li, C. Yu, L. Hu, H. Qiao and Z. Guo, J. Mater. Chem. B, 2020, 8, 4841 DOI: 10.1039/D0TB00097C

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