Issue 46, 2020

Recent developments in the synthesis and applications of chiral ferrocene ligands and organocatalysts in asymmetric catalysis

Abstract

With the ever-present need for novel asymmetric methodologies in organic synthesis to allow chemists to access enantiopure compounds, so too is there a need for new chiral ligands and organocatalysts to affect these transformations. Due to the unique properties of ferrocene and its derivatives, ferrocenyl compounds are unsurprisingly considered privileged structures in asymmetric catalysis. The versatility of the ferrocene moiety gives rise to a vast range of diverse ligand and catalyst motifs which are successful in broad ranges of mechanistically distinct reactions. This review details recent advances in the application of ferrocenyl mono-, bi- and tridentate-ligands and ferrocene-derived organocatalysts in asymmetric catalysis. Given the necessity for the development of new approaches to expand the scope of ferrocenyl ligands and catalysts, this review also illustrates the development of elegant and novel methodologies for the synthesis of ferrocenyl compounds.

Graphical abstract: Recent developments in the synthesis and applications of chiral ferrocene ligands and organocatalysts in asymmetric catalysis

Associated articles

Article information

Article type
Review Article
Submitted
19 Leo 2020
Accepted
24 Mph 2020
First published
26 Mph 2020

Org. Biomol. Chem., 2020,18, 9329-9370

Recent developments in the synthesis and applications of chiral ferrocene ligands and organocatalysts in asymmetric catalysis

L. Cunningham, A. Benson and P. J. Guiry, Org. Biomol. Chem., 2020, 18, 9329 DOI: 10.1039/D0OB01933J

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