Issue 24, 2019

Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation

Abstract

Metal-catalysed ortho-directed C–H functionalization usually faces selectivity issues in the competition between mono- and disubstitution processes. We report herein the ruthenium-catalysed N-directed C–H monoarylation of arylpyrazoles with a selectivity of up to 96% or that generally reaches values above 80%. This selectivity is an effect of solvent-free conditions associated with sulfonate reagents, in the absence of frequently used acidic additives.

Graphical abstract: Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation

Supplementary files

Article information

Article type
Communication
Submitted
08 Mme 2019
Accepted
20 Mot 2019
First published
22 Mot 2019

Org. Biomol. Chem., 2019,17, 5916-5919

Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation

O. Abidi, T. Boubaker, J. Hierso and J. Roger, Org. Biomol. Chem., 2019, 17, 5916 DOI: 10.1039/C9OB00806C

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