Issue 13, 2019

Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

Abstract

Nano-dimensional single crystals of acetylsalicylic acid (aspirin) Form I are generated through sonocrystallization and are shown to exhibit Young's modulus values in the MPa range, which is significantly softer (5-fold reduction) than macro-dimensional single crystals. The change is attributed to structural consequences of the size-dependent surface-to-volume ratio effect, particularly as related to intermolecular forces.

Graphical abstract: Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

Supplementary files

Article information

Article type
Communication
Submitted
10 Mot 2018
Accepted
12 Jan 2018
First published
19 Jan 2018

CrystEngComm, 2019,21, 2049-2052

Author version available

Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

K. M. Hutchins, T. P. Rupasinghe, S. M. Oburn, K. K. Ray, A. V. Tivanski and L. R. MacGillivray, CrystEngComm, 2019, 21, 2049 DOI: 10.1039/C8CE00764K

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