Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

Young Il Yoon; Xin Pang; Sungwook Jung; Guofeng Zhang; Minsuk Kong; Gang Liu; Xiaoyuan Chen

doi:10.1039/C8TB00368H

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics†

Young Il Yoon,‡^ab Xin Pang,‡^c Sungwook Jung,‡^a Guofeng Zhang,^d Minsuk Kong,^e Gang Liu

*^c and Xiaoyuan Chen

*^a

Author affiliations

* Corresponding authors

^a Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland, USA
E-mail: shawn.chen@nih.gov

^b IT and Medical Research Team, Korea Textile Development Institute (KTDI), 136 Gukchaebosangro, Seo-gu, Daegu, South Korea

^c State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
E-mail: gangliu.cmitm@xmu.edu.cn

^d Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institutes of Health (NIH), Bethesda, Maryland, USA

^e Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Smart gold nanoparticle-stabilized microbubbles (SAuMBs) composed of a gas-filled core and shell including smart gold nanoparticles (SAuNPs) which can be aggregated in tumors were applied as ultrasound-mediated cancer theranostics. The gas core in the microstructure enabled the detection of tumors using ultrasound and facilitated the delivery of SAuNPs by sonoporation. The SAuNPs spontaneously aggregated in tumors, which allowed photoacoustic (PA) monitoring and photothermal treatment (PTT) of tumors.

This article is part of the themed collection: International Year of the Periodic Table: Precious metals for cancer treatment

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DOI: https://doi.org/10.1039/C8TB00368H
Article type: Communication
Submitted: 06 Kol 2018
Accepted: 01 Mot 2018
First published: 01 Mot 2018

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J. Mater. Chem. B, 2018,6, 3235-3239

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Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

Y. I. Yoon, X. Pang, S. Jung, G. Zhang, M. Kong, G. Liu and X. Chen, J. Mater. Chem. B, 2018, 6, 3235 DOI: 10.1039/C8TB00368H

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Journal of Materials Chemistry B

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics†

Abstract

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Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

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