Issue 14, 2017

A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway

Abstract

Sodium polysulfides (Na2Sn, n > 1) as important raw materials in the chemical industry can afford hydrogen polysulfides (H2Sn, n > 1) under physiological conditions. Hydrogen polysulfides are important reactive sulfide species that play crucial roles in biological systems. The simple detection of H2Sn in solution and biosystems becomes very important as a consequence of the foregoing applications. Herein, we report a NIR fluorescent chemodosimeter, Cy-Sn, displaying turn-on fluorescence after reaction with H2Sn, which exhibits good selectivity and sensitivity in solution and biosystems. Moreover, it was applied successfully to monitor endogenous hydrogen polysulfides via the cystathionine γ-lyase (CSE) enzymatic pathway during inflammation and anti-inflammation in living RAW 264.7 cells. Mouse experiments indicated that this chemodosimeter has good potential to be employed in the imaging of living biosystems.

Graphical abstract: A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway

Supplementary files

Article information

Article type
Paper
Submitted
10 Phe 2017
Accepted
17 Kol 2017
First published
17 Kol 2017

J. Mater. Chem. B, 2017,5, 2574-2579

A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway

J. Ma, J. Fan, H. Li, Q. Yao, F. Xu, J. Wang and X. Peng, J. Mater. Chem. B, 2017, 5, 2574 DOI: 10.1039/C7TB00098G

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