Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells

Ajay Kumar Jha; Shahida Umar; Rakesh Kumar Arya; Dipak Datta; Atul Goel

doi:10.1039/C6TB01413E

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Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg²⁺ in live cancer cells†

Ajay Kumar Jha,^a Shahida Umar,^a Rakesh Kumar Arya,^b Dipak Datta^b and Atul Goel*^ac

Author affiliations

* Corresponding authors

^a Fluorescent Chemistry Lab, Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India
E-mail: atul_goel@cdri.res.in

^b Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India

^c Academy of Scientific and Innovative Research, New Delhi 110001, India

Abstract

A novel pyrano[3,2-c]julolidin-2-one based fluorescent molecular rotor PYJO4 has been designed and developed for selective ratiometric detection, quantification and imaging of intracellular Hg²⁺ in live cells. The probe operates via a Twisted Intramolecular Charge Transfer (TICT) mechanism and exhibits high selectivity and sensitivity up to 1.14 ppb. PYJO4 coated test strips can be used to detect mercury ions in contaminated water.

This article is part of the themed collection: JMC B Editor’s choice web collection: ‘‘seeing the unseen updated: advances in bioimaging’’

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Article information

DOI: https://doi.org/10.1039/C6TB01413E
Article type: Paper
Submitted: 07 Jan 2016
Accepted: 17 Jan 2016
First published: 17 Jan 2016

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J. Mater. Chem. B, 2016,4, 4934-4940

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Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg²⁺ in live cancer cells

A. K. Jha, S. Umar, R. K. Arya, D. Datta and A. Goel, J. Mater. Chem. B, 2016, 4, 4934 DOI: 10.1039/C6TB01413E

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Journal of Materials Chemistry B