Issue 15, 2016

A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission

Abstract

Dynamic visualization of the morphology of membrane-bound organelles offers useful insights for studying various intracellular activities. Fluorescent probes with superior specificity and photostability are desirable for long-term tracking of these processes. In this work, we present the design and synthesis of an α-cyanostilbene derivative, abbreviated as ASCP, with the aggregation-induced emission (AIE) characteristic, and its application in cell imaging. ASCP can simultaneously label mitochondria and nucleolus in live cells with distinct fluorescence, which is demonstrative of a single molecule with dual-colour organelle imaging.

Graphical abstract: A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission

Supplementary files

Article information

Article type
Paper
Submitted
04 Kol 2016
Accepted
08 Ube 2016
First published
11 Ube 2016

J. Mater. Chem. B, 2016,4, 2614-2619

A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission

C. Y. Y. Yu, W. Zhang, R. T. K. Kwok, C. W. T. Leung, J. W. Y. Lam and B. Z. Tang, J. Mater. Chem. B, 2016, 4, 2614 DOI: 10.1039/C6TB00319B

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