Issue 29, 2016

Copper-catalyzed and iodide-promoted aerobic C–C bond cleavage/C–N bond formation toward the synthesis of amides

Abstract

A copper-catalyzed and iodide-promoted aerobic C–C bond cleavage/C–N bond formation reaction between ketone and simple amine was developed toward the synthesis of amides, which are useful synthetic intermediates in organic synthesis and important skeletons of biologically active molecules. Notably, the reaction conditions are very mild, and preliminary mechanistic investigations indicate that molecular oxygen might be involved in the C–C bond cleavage process.

Graphical abstract: Copper-catalyzed and iodide-promoted aerobic C–C bond cleavage/C–N bond formation toward the synthesis of amides

Supplementary files

Article information

Article type
Communication
Submitted
25 Phe 2016
Accepted
26 Kol 2016
First published
26 Kol 2016

RSC Adv., 2016,6, 24349-24352

Copper-catalyzed and iodide-promoted aerobic C–C bond cleavage/C–N bond formation toward the synthesis of amides

K. Wu, Z. Huang, Y. Ma and A. Lei, RSC Adv., 2016, 6, 24349 DOI: 10.1039/C6RA02153K

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