Issue 22, 2016

Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

Abstract

Two isomorphous cocrystals of nitazoxanide (NTZ) with p-aminosalicylic acid (PASA) and p-aminobenzoic acid (PABA) as well as their alloys were prepared by slurry and grinding techniques. The cocrystals exhibit faster dissolution rates and higher pharmacokinetic properties compared to the reference drug, and surprisingly the cocrystal alloy NTZ-PABA : NTZ-PASA (0.75 : 0.25) exhibited 4 fold higher bioavailability of NTZ in Sprague Dawley rats. This study opens the opportunity for cocrystal alloys as improved medicines.

Graphical abstract: Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

Supplementary files

Article information

Article type
Communication
Submitted
31 Phe 2016
Accepted
15 Kol 2016
First published
18 Kol 2016

Chem. Commun., 2016,52, 4223-4226

Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

K. Suresh, M. K. C. Mannava and A. Nangia, Chem. Commun., 2016, 52, 4223 DOI: 10.1039/C6CC00975A

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