Issue 11, 2015
From the journal:

Organic Chemistry Frontiers

Direct borylation of benzyl alcohol and its analogues in the absence of bases†

Zhi-Chao Cao,a   Fei-Xian Luo,a   Wen-Juan Shia  and  Zhang-Jie Shi*ab  

* Corresponding authors

a Beijing National Laboratory of Molecule Science (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing, China
E-mail: zshi@pku.edu.cn

b State Key Laboratory of Organometallic Chemistry, Chinese Academy of Science, Shanghai, China

Abstract

Direct borylation of arylmethanols to synthesize important and useful benzylboronates was carried out through Pd(OAc)2-catalyzed sp3 C–O activation. This borylation is compatible with various functional groups under mild conditions in the absence of any bases, offering an atom- and step-economical way to produce benzylboron compounds.

Graphical abstract: Direct borylation of benzyl alcohol and its analogues in the absence of bases

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Article information

DOI
https://doi.org/10.1039/C5QO00243E
Article type
Research Article
Submitted
02 Pha 2015
Accepted
02 Leo 2015
First published
10 Leo 2015

Org. Chem. Front., 2015,2, 1505-1510

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Direct borylation of benzyl alcohol and its analogues in the absence of bases

Z. Cao, F. Luo, W. Shi and Z. Shi, Org. Chem. Front., 2015, 2, 1505 DOI: 10.1039/C5QO00243E

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