Issue 17, 2002
From the journal:

Chemical Communications

Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

Martyn Frederickson,a   John R. Cogginsb  and  Chris Abell*a  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ca26@cam.ac.uk

b Division of Biochemistry and Molecular Biology, IBLS, Glasgow University, Glasgow, UK

Abstract

A vinyl fluoride analogue of the intermediate in the reaction catalysed by type II dehydroquinase enzymes has been synthesized over seven steps from (−)-quinic acid and shown to be a potent enzyme inhibitor.

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Article information

DOI
https://doi.org/10.1039/B205105M
Article type
Communication
Submitted
27 Mot 2002
Accepted
08 Upu 2002
First published
26 Upu 2002

Chem. Commun., 2002, 1886-1887

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Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

M. Frederickson, J. R. Coggins and C. Abell, Chem. Commun., 2002, 1886 DOI: 10.1039/B205105M

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