Multiscale aggregation materials for disease therapy and bioanalysis

Abstract

Chemical aggregates span multiple scales, from single molecules to nanoscale assemblies and macroscopic systems, exhibiting diverse functionalities towards biomedical purposes. The development of multiscale aggregation materials provides a powerful strategy to enable innovative solutions for treating diseases and performing bioanalysis. In this review, we summarize our recent progress in leveraging aggregation materials for antimicrobial therapy, bioanalysis, and drug delivery from a multiscale perspective. We highlight the discovery of small molecules, microfluidics-assembled or chemically synthesized nanoscale aggregation materials, and mesoscale biological aggregation interfaces for a broad range of biomedical applications. We also discuss current challenges in developing aggregation materials and explore directions for practical translations.