Issue 32, 2023

Cardiac organoid: multiple construction approaches and potential applications

Abstract

The human cardiac organoid (hCO) is three-dimensional tissue model that is similar to an in vivo organ and has great potential on heart development biology, disease modeling, drug screening and regenerative medicine. However, the construction of hCO presents a unique challenge compared with other organoids such as the lung, small intestine, pancreas, liver. Since heart disease is the dominant cause of death and the treatment of such disease is one of the most unmet medical needs worldwide, developing technologies for the construction and application of hCO is a critical task for the scientific community. In this review, we discuss the current classification and construction methods of hCO. In addition, we describe its applications in drug screening, disease modeling, and regenerative medicine. Finally, we propose the limitations of the cardiac organoid and future research directions. A detailed understanding of hCO will provide ways to improve its construction and expand its applications.

Graphical abstract: Cardiac organoid: multiple construction approaches and potential applications

Article information

Article type
Review Article
Submitted
10 Mme 2023
Accepted
09 Upu 2023
First published
11 Upu 2023

J. Mater. Chem. B, 2023,11, 7567-7581

Cardiac organoid: multiple construction approaches and potential applications

Z. Yang, Y. Zhang, J. Wang, J. Yin, Z. Wang and R. Pei, J. Mater. Chem. B, 2023, 11, 7567 DOI: 10.1039/D3TB00783A

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