Issue 14, 2023

Molecular substrates for the construction of afterglow imaging probes in disease diagnosis and treatment

Abstract

Afterglow, an intrinsic phenomenon of persistent luminescence emitted from chemical defects after light irradiation, has shown tremendous promise for applications in bioimaging with an ultra-high signal-to-background ratio (SBR) in vivo. In contrast to inorganic phosphor materials, organic afterglow substrates possess high biocompatibility and structural diversity for the construction of molecular afterglow imaging probes with an ideal intensity, wavelength, and duration for in vivo imaging. In this tutorial review, we aim to introduce the recent advances in molecular afterglow imaging with a comprehensive summary of the reported afterglow substrates and mechanisms. Molecular designs of multicomponent afterglow imaging probes are also introduced with their biomedical applications in disease diagnosis and treatment. Lastly, future perspectives and potential challenges of molecular afterglow imaging in preclinical uses and clinical translations are discussed.

Graphical abstract: Molecular substrates for the construction of afterglow imaging probes in disease diagnosis and treatment

Article information

Article type
Tutorial Review
Submitted
26 Ube 2023
First published
23 Jan 2023

Chem. Soc. Rev., 2023,52, 4549-4566

Molecular substrates for the construction of afterglow imaging probes in disease diagnosis and treatment

X. Wang and K. Pu, Chem. Soc. Rev., 2023, 52, 4549 DOI: 10.1039/D3CS00006K

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