Issue 64, 2023

Pd-catalyzed regioselective rollover dual C–H annulation cascade: facile approach to phenanthrene derivatives

Abstract

Annulations of unsaturated systems through C–H activation represent a powerful tool for producing multicyclic scaffolds. Having coordinating centers in both annulation partners (a dual coordination strategy) would afford remarkable selectivities in the outcomes. Along this concept, we report herein a Pd-catalyzed regioselective rollover cascade dual C–H annulation of o-arylphenols with alkynols for constructing phenanthrene scaffolds. Control, KIE and deuteration studies were conducted to determine the reaction mechanism, and downstream transformations and scaled-up reactions were carried out to assess the robustness of the transformation.

Graphical abstract: Pd-catalyzed regioselective rollover dual C–H annulation cascade: facile approach to phenanthrene derivatives

Supplementary files

Article information

Article type
Communication
Submitted
25 Mot 2023
Accepted
30 Jan 2023
First published
01 Upu 2023

Chem. Commun., 2023,59, 9714-9717

Pd-catalyzed regioselective rollover dual C–H annulation cascade: facile approach to phenanthrene derivatives

M. N. Kumar, V. Suresh, A. Nagireddy, J. B. Nanubolu and M. S. Reddy, Chem. Commun., 2023, 59, 9714 DOI: 10.1039/D3CC02523C

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