Issue 3, 2019

Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

Abstract

The natural product A-94964 is a uridine-derived nucleoside antibiotic isolated from Streptomyces sp. SANK 60404. In this study, we propose a biosynthetic pathway for A-94964 using gene deletion experiments coupled with in silico analysis of the biosynthetic gene cluster. This study provides insights into the unique biosynthetic pathway for A-94964.

Graphical abstract: Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

Supplementary files

Article information

Article type
Communication
Submitted
07 Pun 2018
Accepted
13 Tsh 2018
First published
13 Tsh 2018

Org. Biomol. Chem., 2019,17, 461-466

Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

T. Shiraishi, M. Nishiyama and T. Kuzuyama, Org. Biomol. Chem., 2019, 17, 461 DOI: 10.1039/C8OB02765J

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