Issue 10, 2018
From the journal:

New Journal of Chemistry

A camphor based 1,3-diamine Ru(ii) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding†

Milan M. Milutinović, ORCID logo ab   Živadin D. Bugarčić ORCID logo ‡b  and  René Wilhelm ORCID logo *a  

* Corresponding authors

a Department of Organic Chemistry, University of Paderborn, Warburgerstraße 100, 33098 Paderborn, Germany
E-mail: rene.wilhelm@uni-paderborn.de

b Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia

Abstract

The synthesis and reactivity of a new ruthenium(II) terpyridine complex with a bidentate enantiopure camphor based diamine ligand is described. Reactivity measurements of the Ru(II) complex showed a high affinity towards guanosine-5′-monophosphate as a model for DNA bases. Furthermore, the Ru(II) complex was found to interact with CT-DNA. This suggests the high potential of the newly synthesized ruthenium complex as an antitumor agent.

Graphical abstract: A camphor based 1,3-diamine Ru(ii) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding

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Article information

DOI
https://doi.org/10.1039/C7NJ04674J
Article type
Letter
Submitted
29 Pun 2017
Accepted
24 Phe 2018
First published
05 Kol 2018

New J. Chem., 2018,42, 7607-7611

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A camphor based 1,3-diamine Ru(II) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding

M. M. Milutinović, Ž. D. Bugarčić and R. Wilhelm, New J. Chem., 2018, 42, 7607 DOI: 10.1039/C7NJ04674J

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