Issue 74, 2016

Highly selective intramolecular addition of C–N and S–N bonds to alkynes catalyzed by palladium: a practical access to two distinct functional indoles

Abstract

Palladium-catalyzed highly selective intramolecular addition of C–N and S–N bonds to alkynes has been achieved, and two distinct functional indoles were synthesized rapidly from the same set of substrates in a catalyst-controlled manner. This protocol features high atom economy, moderate to high yields and excellent selectivity, thus affording a practical approach to functional indoles.

Graphical abstract: Highly selective intramolecular addition of C–N and S–N bonds to alkynes catalyzed by palladium: a practical access to two distinct functional indoles

Supplementary files

Article information

Article type
Paper
Submitted
20 Jan 2016
Accepted
18 Upu 2016
First published
18 Upu 2016

RSC Adv., 2016,6, 70682-70690

Highly selective intramolecular addition of C–N and S–N bonds to alkynes catalyzed by palladium: a practical access to two distinct functional indoles

C. Wu, F. Zhao, Y. Du, L. Zhao, L. Chen, J. Wang and H. Liu, RSC Adv., 2016, 6, 70682 DOI: 10.1039/C6RA15945A

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