Issue 51, 2016

Fei-Phos ligand-controlled asymmetric palladium-catalyzed allylic substitutions with structurally diverse nucleophiles: scope and limitations

Abstract

To shed light on the scope and limitations of palladium-catalyzed allylic alkylation in the presence of chiral trans-1,2-diaminocyclohexane-derived Fei-Phos as an effective phosphine ligand, the asymmetric palladium-catalysed alkylation of structurally diverse hard/soft nucleophiles, including allylic etherification of alcohols and the allylic alkylation of activated methylene compounds, indoles, and aromatic amines were investigated in this study; the corresponding products with various functional groups were achieved in good yield and with high enantioselectivity (up to 99% ee).

Graphical abstract: Fei-Phos ligand-controlled asymmetric palladium-catalyzed allylic substitutions with structurally diverse nucleophiles: scope and limitations

Supplementary files

Article information

Article type
Paper
Submitted
14 Mme 2016
Accepted
25 Mme 2016
First published
26 Mme 2016

RSC Adv., 2016,6, 45495-45502

Fei-Phos ligand-controlled asymmetric palladium-catalyzed allylic substitutions with structurally diverse nucleophiles: scope and limitations

J. Xu, F. Ye, X. Bai, J. Zhang, Z. Xu, Z. Zheng and L. Xu, RSC Adv., 2016, 6, 45495 DOI: 10.1039/C6RA09657C

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