Issue 42, 2016

Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines

Abstract

An efficient copper-catalyzed oxidative decarboxylative amination of arylacetic acids with 2-aminobenzoketones and ammonium acetate under an oxygen atmosphere was first developed. This reaction represents a novel avenue for 2-arylquinazolines in good to excellent yields via multiple C–N bond formations. This protocol features inexpensive copper as the catalyst, molecular oxygen as the sole oxidant, H2O and CO2 as wastes, and a broad substrate scope.

Graphical abstract: Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines

Supplementary files

Article information

Article type
Paper
Submitted
16 Kol 2016
Accepted
04 Mme 2016
First published
05 Mme 2016

RSC Adv., 2016,6, 36192-36197

Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines

Y. Yan, M. Shi, B. Niu, X. Meng, C. Zhu, G. Liu, T. Chen and Y. Liu, RSC Adv., 2016, 6, 36192 DOI: 10.1039/C6RA04195G

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