Highlight
New strategies and applications using electrophilic cyanide-transfer reagents under transition metal-free conditions
The use of electrophilic cyanide-transfer reagents has become a versatile strategy to access important structural motives in a complementary way compared to other methods.
Ruthenium-catalysed hydrosilylation of carbon–carbon multiple bonds
Recent advances in ruthenium-catalysed hydrosilylation of C–C multiple bonds and its application to organic synthesis are highlighted.
C(sp3)–H bond functionalization by sequential hydride transfer/cyclization: electronic effect and steric effect controlled regioselectivity
The electronic effect and steric effect have a dramatic impact on the fascinating cascade [1,n]-hydride transfer/cyclization. The regioselectivity of two potential hydrogen donors could be perfectly tuned to construct different skeletons.
Photoredox sheds new light on nickel catalysis: from carbon–carbon to carbon–heteroatom bond formation
Recent emergence of photoredox/nickel dual catalysis to generate carbon–carbon and carbon–heteroatom bonds is highlighted.
A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations
Fluorinated solvents like 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have recently emerged as a remarkable synthetic hint allowing challenging C–H activation reactions.
Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations
This review covers new developments in the transition metal-catalyzed allylic alkylations of non-stabilized enolates, preferentially generated from ketone, esters or amides.
Beyond Fischer and Schrock carbenes: non-heteroatom-stabilized group 6 metal carbene complexes – a general overview
Non-heteroatom-stabilized group 6 metal carbene complexes: versatile reagents or intermediates in stoichiometric or catalytic reactions in organic synthesis.
Recent progress in rhodium-catalyzed hydroaminomethylation
This review covers the recent studies featuring the development of catalysts for alkene hydroaminomethylation.
Learning lessons from directed evolution of stereoselective enzymes
With the advent of directed evolution of stereoselective enzymes almost 20 years ago and the rapid development of this exciting area of research, the traditional limitations of biocatalysts in organic chemistry have been eliminated.
Synthesis and reactivity of alkoxy-activated cyclobutane-1,1-dicarboxylates
Donor–acceptor (DA) cyclopropanes are extensively studied and well established as building blocks for the synthesis of highly substituted carbo- and heterocyclic compounds. Despite of similar ring strain, the homologous DA cyclobutanes were long ignored. This personal account details our group's research towards the application of DA cyclobutanes in cycloaddition chemistry.
Chirality transfer in metal-catalysed intermolecular addition reactions involving allenes
This review covers chirality transfer in metal-catalysed intermolecular addition reactions involving allenes, including axial-to-central chirality transfer, asymmetric catalysis and racemization.
About this collection
Review-type articles published by Organic Chemistry Frontiers in 2016 are collated as below for the benefit of readers.