More than a delivery system: the evolving role of lipid-based nanoparticles

Senjuti Karmaker, Plinio D. Rosales, Barath Tirumuruhan, Amartya Viravalli and Natalie Boehnke

Nanoscale, 2025, 17, 11864
DOI: 10.1039/D4NR04508D

Versatility of LNPs across different administration routes for targeted RNA delivery

Muhammed Boye Jallow, Kun Huang and Min Qiu

J. Mater. Chem. B, 2025, 13, 7637
DOI: 10.1039/D5TB00575B

GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting

Zhijie Liang, Shaorong Li, Huali Huang, Shuying Luo, Hongmian Jiang, Lifeng Luo, Jinzhuai Li and Kun Zhao

J. Mater. Chem. B, 2026
DOI: 10.1039/D6TB00003G

LncRNA NRIR inhibits osteogenesis by promoting macrophage M1 polarization through RSAD2/NF-κB axis in peri-implantitis

Renshengjie Zhao, Lan Wang, Yang Zhou, Keming Xiao, Qiqi Liu and Ke Yu

Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1650984

Reprogramming Atherosclerosis: Precision Drug Delivery, Nanomedicine, and Immune-Targeted Therapies for Cardiovascular Risk Reduction

Paschalis Karakasis, Panagiotis Theofilis, Panayotis K. Vlachakis, Konstantinos Grigoriou, Dimitrios Patoulias, Antonios P. Antoniadis and Nikolaos Fragakis

Pharmaceutics, 2025, 17, 1028
DOI: 10.3390/pharmaceutics17081028

Sustained modulation of tumor microenvironment via sorafenib-loaded mesoporous ferromanganese nanozymes for enhanced apoptosis-ferroptosis cancer therapy

Guanghui Lin, Jieyao Chen, Xiaojia Liu, Yitong Lin, Xudong Zhu, Guotao Yuan, Bowen Yang, Shuanshuan Guo, Yue Pan and Jianhua Zhou

Chinese Chemical Letters, 2025, 36, 111018
DOI: 10.1016/j.cclet.2025.111018

Recent Update on siRNA Therapeutics

Oluwakemi Ebenezer, Abel Kolawole Oyebamiji, John Oludele Olanlokun, Jack A. Tuszynski and Gane Ka-Shu Wong

IJMS, 2025, 26, 3456
DOI: 10.3390/ijms26083456

Advancing mRNA vaccines for infectious diseases: key components, innovations, and clinical progress

Sha Li, Lu Zheng, Jingyi Zhong and Xihui Gao

Essays in Biochemistry, 2025, 69, 109
DOI: 10.1042/EBC20253009

A Sprayable Hydrogel Based on Biomimetic Polypeptide‐Modified Lipid Nanoparticles for Treating Non‐Compressible Hemorrhaging

Yajun Feng, Zixuan Zhang, Wenjing Yan, Zhuo Zhang, Yang Li, Chenhui Zhu and Daidi Fan

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202500908

Guiding design and performance of nonviral nucleic acid delivery vehicles via machine learning

John A. Hutchinson, Sidharth Panda, Plinio D. Rosales, Janey P. Sowada, Miles S. Willis, Michael C. Leyden, Prodromos Daoutidis and Theresa M. Reineke

Advanced Drug Delivery Reviews, 2026, 229, 115739
DOI: 10.1016/j.addr.2025.115739

Exploring the Complexities of Hepatic Encephalopathy: Pathophysiology and Innovative Therapeutic Options

Faizan E Mustaffa, Munawar Ali, Hafiz Muhammad Sultan and Syeda Areej Imran

Prospect. Pharm. Sci., 2025
DOI: 10.56782/pps.402

Natural lipid-based nanoformulations for enhancing hepatoprotective activity: mechanisms, efficacy, and clinical translation

Jitendra Patel, Harekrishna Roy, Deepak S. Khobragade, Surendra Agrawal, Nihar Ranjan Das, Rukmani Patel, Vijay Patel and Poonam Lal

Health Nanotechnol, 2025, 1
DOI: 10.1186/s44301-025-00010-8

Oral liver-targeted delivery systems for anti-hyperglycemic therapy: From passive to active targeting strategies

Yahui Zhang, Yanping Sun, Jiayi Liu, Jie Dong, Chunlei Cao, Mengge Qi, Shuo Li, Huimin Zhang, Zibin Gao and Huijia Song

Colloids and Surfaces B: Biointerfaces, 2026, 266, 115842
DOI: 10.1016/j.colsurfb.2026.115842

Advances in mRNA LNP-Based Cancer Vaccines: Mechanisms, Formulation Aspects, Challenges, and Future Directions

Eslam Ramadan, Ali Ahmed and Youssef Wahib Naguib

JPM, 2024, 14, 1092
DOI: 10.3390/jpm14111092

Precision Drug Delivery to the Liver: A Nanoparticle Approach

Krishna Yadav, Ajazuddin, Mukesh Sharma, Kushagra Nagori, Parag Jain, Sunita Minz, Manju Rawat Singh, Deependra Singh and Madhulika Pradhan

CDD, 2026, 23, 1
DOI: 10.2174/0115672018350438250311045745

Lipid‐Based Nanoplatforms in Hepatology: From Rational Design to Clinical Translation Challenges

Jie Wang, Qian Zhang, Lin Yang, Zijian Cheng, Chunhong Wang, Runlin Song, Honglan Dai and Xinxin Zhang

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70025

Targeted Hepatic Delivery of Bioactive Molecules via Nanovesicles: Recent Developments and Emerging Directions

Alessia Rita Canestrale, Sharad Kholia, Veronica Dimuccio and Maria Beatriz Herrera Sanchez

JPM, 2025, 16, 1
DOI: 10.3390/jpm16010001

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles

Francesca Ferraresso, Chad W. Skaer, Katherine Badior, Serena M. Pulente, Manoj Paul, Laura Ketelboeter, Taylor H.S. Chen, Pieter R. Cullis, Sweta Gupta, Amy Shapiro, Erin E. Mulvihill and Christian J. Kastrup

Molecular Therapy Methods & Clinical Development, 2025, 33, 101557
DOI: 10.1016/j.omtm.2025.101557

Emerging DNA- and RNA-based therapeutic strategies in hepatocellular carcinoma: A molecular approach to precision medicine

Zulfa Nooreen, Ankita Wal, Anjali Shukla, A. Venkata Badarinath, Nishant Kumar, Tanmay Sarma, Abida Khan and Amin Gasmi

Letters in Drug Design & Discovery, 2025, 22, 100268
DOI: 10.1016/j.lddd.2025.100268

Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines

Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M. Merkel and Andrea Hawe

WIREs Nanomed Nanobiotechnol, 2026, 18
DOI: 10.1002/wnan.70053

PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing

Teresa Ferrillo, Federica Santoro, Paola De Cicco, Michele Guida, Alfonso Carotenuto, Diego Brancaccio, Francesca Borrelli, Thomas Lee Moore and Fabiana Quaglia

Journal of Colloid and Interface Science, 2026, 721, 140735
DOI: 10.1016/j.jcis.2026.140735

Why do lipid nanoparticles target the liver? Understanding of biodistribution and liver-specific tropism

Mahboubeh Hosseini-Kharat, Kristen E. Bremmell and Clive A. Prestidge

Molecular Therapy Methods & Clinical Development, 2025, 33, 101436
DOI: 10.1016/j.omtm.2025.101436

Tomas Do, Silvia Vaculciakova, Katarzyna Kluska, Manuel David Peris-Díaz, Jan Priborsky, Roman Guran, Artur Krężel, Vojtech Adam and Ondrej Zitka

Chemosphere, 2024, 364, 142988
DOI: 10.1016/j.chemosphere.2024.142988

Targeted drug delivery systems for atherosclerosis

Liangxing Tu, Zijian Zou, Ye Yang, Siying Wang, Banghuai Xing, Jianfang Feng, Yi Jin and Meng Cheng

J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03384-0

Ferroptosis and the cGAS–STING pathway into precision nano-immuno-theranostics: A mechanistic paradigm for reversing drug resistance in hepatocellular carcinoma

Alaa Elmetwalli

Drug Resistance Updates, 2026, 84, 101326
DOI: 10.1016/j.drup.2025.101326

Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Yue Yuan, Jiaxuan Li, Min Chen, Ying Zhao, Bixiang Zhang, Xiaoping Chen, Jianping Zhao, Huifang Liang and Qian Chen

Journal of Controlled Release, 2024, 376, 318
DOI: 10.1016/j.jconrel.2024.10.012

Nutritional and Therapeutic Potential of Longan Fruit By-products for Liver Diseases: Pathway to Functional Foods

Idris Kaida Zubairu, Kanyasiri Rakariyatham, Shitapan Bai-Ngew, Noppol Leksawasdi, Joe M. Regenstein, Fei Lao, Hui Hong, Weon-Sun Shin, Khalid J. Alzahrani and Yuthana Phimolsiripol

Curr Nutr Rep, 2025, 14
DOI: 10.1007/s13668-025-00617-4

In vitro and in vivo correlation of injectable lipid-based nanomedicines: From dissolution to protein coronas

Huan Wang, Xiying Wu, Junji Wang, Xiaoyi Wang and Ying Lu

Materials Today Bio, 2025, 35, 102393
DOI: 10.1016/j.mtbio.2025.102393

Emerging nanomedicine for liver diseases treatment

Yawen Zhu, Dongxue Ge, Jinglin Wang, Hao Sun, Wei Li and Haozhen Ren

J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03832-x

Advances in vehicles for in situ delivery: From classical vectors to biologically inspired structures

Hengyi Wang, Xiaoyan Tang, Xinyao Pan, Hongjie Tang, Jie Gao and Qi Li

Synthetic and Systems Biotechnology, 2026, 13, 446
DOI: 10.1016/j.synbio.2026.02.013

Innovative Lipid-Based Nanobiotechnology: Diagnostics and Medicine

Sung Eun Seo, Kyung Ho Kim, Shubham Singh, Jia-Sin Chen, Sumio Iijima, Chi-An Cheng, Yong-Sang Ryu, Hyun Seok Song, Wei-Peng Li and Oh Seok Kwon

ACS Nano, 2026, 20, 3944
DOI: 10.1021/acsnano.5c16718