ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases

Jingjing Zhang, Linzhu Li, Qianwen Guo, Xuesong Liu, Qian Qiao, Xuerui Ye, Hongyang Ding, Yi Liu, Kaikai Wang, Haoling Zhang and Lu Cheng

JIR, 2026, Volume 19, 1
DOI: 10.2147/JIR.S584582

Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths ? (a Review)

Anton Tkachenko, Anatolii Onishchenko and Volodymyr Prokopiuk

Curr. Pharmacol. Rep., 2023, 9, 580
DOI: 10.1007/s40495-023-00339-7

Naja naja snake venom-induced local toxicities in mice is by inflammasome activation

Manuganahalli B. Nandana, Madeva Bharatha, Bannikuppe S. Vishwanath and Rajesh Rajaiah

Toxicon, 2024, 238, 107590
DOI: 10.1016/j.toxicon.2023.107590

The role of inflammasomes in human diseases and their potential as therapeutic targets

Jing Yao, Keenan Sterling, Zhe Wang, Yun Zhang and Weihong Song

Sig Transduct Target Ther, 2024, 9
DOI: 10.1038/s41392-023-01687-y

Sepsis-Induced Acute Lung Injury Is Alleviated by Small Molecules from Dietary Plants via Pyroptosis Modulation

Jiasi Wu, Yuejia Lan, Jinghan Wu and Keli Zhu

J. Agric. Food Chem., 2023, 71, 12153
DOI: 10.1021/acs.jafc.2c08926

Potential mechanisms of natural products in improving gouty arthritis: Focusing on NLRP3 inflammasome regulation

Yunhao Yi, Yanling Chen, Wuchaonan Liu, Jingjing Yang, Le Yang, Jing Liu, Shengping Luo, Qianru Zeng, Tao Gao and Yihui Deng

Journal of Pharmaceutical Analysis, 2026, 101563
DOI: 10.1016/j.jpha.2026.101563

Sennoside A alleviates sepsis-triggered acute kidney injury via activating SIRT1 signaling pathway

Shaohua Peng, Kaiping Deng and Yan Xue

J Mol Histol, 2026, 57
DOI: 10.1007/s10735-025-10685-z

Role of inflammasomes in cancer immunity: mechanisms and therapeutic potential

Vivek Singh, Saba Ubaid, Mohammad Kashif, Tanvi Singh, Gaurav Singh, Roma Pahwa and Anand Singh

J Exp Clin Cancer Res, 2025, 44
DOI: 10.1186/s13046-025-03366-y

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang and You Zhou

Advanced Science, 2026
DOI: 10.1002/advs.75704

Lappaconitine hydrobromide prevents NLRP3-GSDMD-mediated pyroptosis to alleviate sepsis-induced acute lung injury by enhancing NR1H3

Yuejia Lan, Qingrui Zhong, Hongkai Huang, Xiao Deng, Lu Yang, Jiayi Sun, Mingyang Liu, Xianli Meng and Jiasi Wu

Journal of Pharmaceutical Analysis, 2026, 101631
DOI: 10.1016/j.jpha.2026.101631

Pyroptotic cell death: an emerging therapeutic opportunity for radiotherapy

Hongbin Li, Tiantian Yang, Jialin Zhang, Kai Xue, Xiaoli Ma, Boyi Yu and Xiaodong Jin

Cell Death Discov., 2024, 10
DOI: 10.1038/s41420-024-01802-0

Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7

Xiangyu Jin, Didi Liu, Xinru Zhou, Xianyu Luo, Qian Huang and Yi Huang

Cell Reports Medicine, 2023, 4, 101310
DOI: 10.1016/j.xcrm.2023.101310

A comprehensive review of natural product-derived compounds acting on P2X7R: The promising therapeutic drugs in disorders

Zhenling Liu, Wenjin Liu, Mengyao Han, Mingzhu Wang, Yinchao Li, Yongfang Yao and Yongtao Duan

Phytomedicine, 2024, 128, 155334
DOI: 10.1016/j.phymed.2023.155334

Potential components and action mechanism of Tongzhi Surunjiang Pills against acute gouty arthritis: UPLC-MS/MS, network pharmacology, molecular docking, and transcriptomic analysis

Wanting Fu, Aoqi Ye, Huimin Yang, Xia Hou, Zhongjing Wang, Zhun Hu, Xiang Yu, Xindi Li, Zejun Yu, Yang Li, Yinsheng Qiu, Zhinan Mei and Lingyun Xu

Journal of Ethnopharmacology, 2026, 354, 120516
DOI: 10.1016/j.jep.2025.120516

Tongfu-Xingshen Capsule ameliorates ischemic stroke by inhibiting pyroptosis-mediated neuroinflammation

Qi-Hong Lv, Tian Hu, Jian-Peng Xu, Xin-Yi Xu, Jie Ouyang, Dan Wu, Xin Du, Yu-Hui Qiu, Jia-Yi Zheng, Li Guan, Guang-Liang Wu, Shi-Jie Zhang and Ye-Feng Cai

Journal of Ethnopharmacology, 2026, 366, 121565
DOI: 10.1016/j.jep.2026.121565

Electroacupuncture Alleviates Lung Injury in CpG1826-Challenged Mice via Modulating CD39-NLRP3 Pathway

Jiasi Wu, Xin Xiong and Xiumin Hu

JIR, 2023, Volume 16, 3245
DOI: 10.2147/JIR.S413892

Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors

Rominah Onintsoa Diarimalala, Yanhong Wei, Da Hu and Kanghong Hu

Front. Cell. Infect. Microbiol., 2023, 13
DOI: 10.3389/fcimb.2023.1218039

The intricate interactions between inflammasomes and bacterial pathogens: Roles, mechanisms, and therapeutic potentials

Jin Kyung Kim, Asmita Sapkota, Taylor Roh and Eun-Kyeong Jo

Pharmacology & Therapeutics, 2025, 265, 108756
DOI: 10.1016/j.pharmthera.2024.108756

The NLRP3 inflammasome in urogenital cancers: structure, dual function, and therapeutic potential

Weiming Sun, Ruiting Ma, Rui Zhao, Jiaju Tian and Wenhui Liu

Front. Oncol., 2025, 15
DOI: 10.3389/fonc.2025.1593774